NOTA
Based on 1 Customer Validation
NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect. NOTA can be used in multiple myeloma, breast cancer, lymphoma and myocardial infarction research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 56491-86-2
- 分子式: C12H21N3O6
- 分子量:303.31
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Radionuclide-Drug Conjugates (RDCs) アイソフォーム固有の製品をすべて表示
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生物活性
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RDC Bifunctional Chelator |
NOTA participates in the synthesis of 68Ga-NOTA-RGD for MicroPET/CT imaging of αvβ3 integrin in rat myocardial infarction[4].
NOTA participates in the synthesis of [68Ga]Ga-NOTA-Nb1053 for immunoPET imaging of multiple myeloma[5].
NOTA is a superior chelator to DOTA for PET imaging with 64Cu-labeled TRC105 in 4T1 murine breast tumor-bearing mice[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 56491-86-2
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性状 Solid
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分子量 303.31
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分子式 C12H21N3O6
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Color White to off-white
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SMILES
O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CC1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
H2O : 50 mg/mL (164.85 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (329.70 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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データシート (276 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Singh AN, et al. Multivalent bifunctional chelator scaffolds for gallium-68 based positron emission tomography imaging probe design: signal amplification via multivalency. Bioconjug Chem. 2011;22(8):1650-1662. [Content Brief]
[2]. Liao AH, et al. Evaluation of 18F-labeled targeted perfluorocarbon-filled albumin microbubbles as a probe for microUS and microPET in tumor-bearing mice. Ultrasonics. 2013;53(2):320-327. [Content Brief]
[3]. Poschenrieder A, et al. [64Cu]NOTA-pentixather enables high resolution PET imaging of CXCR4 expression in a preclinical lymphoma model. EJNMMI Radiopharm Chem. 2017;2(1):2. [Content Brief]
[4]. Menichetti L, et al. MicroPET/CT imaging of αvβ₃ integrin via a novel ⁶⁸Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction. Eur J Nucl Med Mol Imaging. 2013 Aug;40(8):1265-74. [Content Brief]
[5]. Wang C, et al. ImmunoPET imaging of multiple myeloma with [68Ga]Ga-NOTA-Nb1053. Eur J Nucl Med Mol Imaging. 2021 Aug;48(9):2749-2760. [Content Brief]
[6]. Zhang Y, et al. Positron emission tomography imaging of CD105 expression with a 64Cu-labeled monoclonal antibody: NOTA is superior to DOTA. PLoS One. 2011;6(12):e28005. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.2970 mL | 16.4848 mL | 32.9696 mL | 82.4239 mL |
| 5 mM | 0.6594 mL | 3.2970 mL | 6.5939 mL | 16.4848 mL | |
| 10 mM | 0.3297 mL | 1.6485 mL | 3.2970 mL | 8.2424 mL | |
| 15 mM | 0.2198 mL | 1.0990 mL | 2.1980 mL | 5.4949 mL | |
| 20 mM | 0.1648 mL | 0.8242 mL | 1.6485 mL | 4.1212 mL | |
| 25 mM | 0.1319 mL | 0.6594 mL | 1.3188 mL | 3.2970 mL | |
| 30 mM | 0.1099 mL | 0.5495 mL | 1.0990 mL | 2.7475 mL | |
| 40 mM | 0.0824 mL | 0.4121 mL | 0.8242 mL | 2.0606 mL | |
| 50 mM | 0.0659 mL | 0.3297 mL | 0.6594 mL | 1.6485 mL | |
| 60 mM | 0.0549 mL | 0.2747 mL | 0.5495 mL | 1.3737 mL | |
| 80 mM | 0.0412 mL | 0.2061 mL | 0.4121 mL | 1.0303 mL | |
| 100 mM | 0.0330 mL | 0.1648 mL | 0.3297 mL | 0.8242 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
NOTA 関連分類
HY-134418 関連分類
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