OM99-2
OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM. OM99-2 is significantly advanced the development of BACE1 inhibitor. OM99-2 has the potential for the research of the Alzheimer's disease.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 314266-76-7
- 分子式: C41H64N8O14
- 分子量:892.99
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-16759A
Verubecestat TFABACE1/2 Inhibitor -
HY-10472
LY2811376BACE1 Inhibitor -
HY-13240A
LY2886721 hydrochlorideBACE1 Inhibitor -
HY-10133
β-Secretase Inhibitor IVBACE-1 Inhibitor -
HY-136742
BACE2-IN-1BACE2 Inhibitor -
HY-12938
AMG-8718BACE1 Inhibitor -
HY-100182
BACE1-IN-1BACE1/2 Inhibitor -
HY-100740C
(1α,1'S,4β)-LanabecestatLanabecestat Enantiomer -
HY-10472R
LY2811376 (Standard)Reference Standard -
HY-100182R
BACE1-IN-1 (Standard)Reference Standard -
HY-10133R
β-Secretase Inhibitor IV (Standard)BACE-1 Inhibitor -
HY-100740CR
(1α,1'S,4β)-Lanabecestat (Standard)Lanabecestat Enantiomer
生物活性
製品説明
IC50 & Target
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BACE1 |
体外実験
Memapsin 2 (BACE) is an aspartyl protease known as beta-secretase that acts on the production of the beta-amyloid peptide in the human brain[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 314266-76-7
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分子量 892.99
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分子式 C41H64N8O14
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
純度とドキュメンテーション
参考文献
[1]. Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523. [Content Brief]
[2]. Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4. [Content Brief]
[3]. Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119. [Content Brief]
[4]. Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
OM99-2 関連分類
HY-P2713 関連分類
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