p,p'-DDE
Based on 2 publication(s) in Google Scholar
p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.91%
- CAS 番号: 72-55-9
- 分子式: C14H8Cl4
- 分子量:318.03
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Metabolism/Protease Compound Library
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HY-L040
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MedChemExpress（MCE）の使用を引用している文献 p,p'-DDE
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生物活性
p,p'-DDE (0.2 μM) can effectively inhibit the transcriptional activity of the androgen receptor induced by androgens[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
p,p'-DDE (100 mg/kg; oral gavage; from 25-57 days old) can delay the onset of puberty in weanling male rats, while increasing their body weight and without reducing the serum testosterone levels[1].
p,p'-DDE (200 mg/kg; oral gavage; 4 days) can significantly reduce the weights of androgen-dependent seminal vesicles and prostates and alter related gene expression in 120-day-old male rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 72-55-9
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性状 Solid
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分子量 318.03
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分子式 C14H8Cl4
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Color White to off-white
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SMILES
Cl/C(Cl)=C(C1=CC=C(Cl)C=C1)/C2=CC=C(Cl)C=C2
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別名
4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene; 2,2-ビス(4-クロロフェニル)-1,1-ジクロロエチレン
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Ecotoxicol Environ Saf
Mechanistic investigation of DDT/DDE in MASLD/MASH pathogenesis: An integrated network toxicology and transcriptomics approach. [Abstract]2025 Nov 15:307:119390. PMID: 41232492
溶剤 & 溶解度
DMSO : 100 mg/mL (314.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.86 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1444 mL | 15.7218 mL | 31.4436 mL | 78.6089 mL |
| 5 mM | 0.6289 mL | 3.1444 mL | 6.2887 mL | 15.7218 mL | |
| 10 mM | 0.3144 mL | 1.5722 mL | 3.1444 mL | 7.8609 mL | |
| 15 mM | 0.2096 mL | 1.0481 mL | 2.0962 mL | 5.2406 mL | |
| 20 mM | 0.1572 mL | 0.7861 mL | 1.5722 mL | 3.9304 mL | |
| 25 mM | 0.1258 mL | 0.6289 mL | 1.2577 mL | 3.1444 mL | |
| 30 mM | 0.1048 mL | 0.5241 mL | 1.0481 mL | 2.6203 mL | |
| 40 mM | 0.0786 mL | 0.3930 mL | 0.7861 mL | 1.9652 mL | |
| 50 mM | 0.0629 mL | 0.3144 mL | 0.6289 mL | 1.5722 mL | |
| 60 mM | 0.0524 mL | 0.2620 mL | 0.5241 mL | 1.3101 mL | |
| 80 mM | 0.0393 mL | 0.1965 mL | 0.3930 mL | 0.9826 mL | |
| 100 mM | 0.0314 mL | 0.1572 mL | 0.3144 mL | 0.7861 mL |
p,p'-DDE 関連分類
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