Phthalide
Based on 1 Customer Validation
Phthalide is a chemical scaffold. Phthalide derivatives act as potent blood-brain barrier modulators. Phthalide exhibits significant anti-inflammatory activity. Some phthalide derivatives possess anti-inflammatory activity. The phthalide derivative Senkyunolide I shows analgesic effects and ameliorates cerebral edema and cerebral infarction volume in rats with focal cerebral ischemia-reperfusion injury. Phthalide can be used in research related to glioma, rheumatoid arthritis, malaria, bacterial infection, fungal infection and ischemic stroke.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.94%
- CAS 番号: 87-41-2
- 分子式: C8H6O2
- 分子量:134.13
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Phthalide exhibits remarkable anti-inflammatory activity and can serve as a chemical scaffold for anti-inflammatory agents[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 87-41-2
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性状 Solid
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分子量 134.13
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分子式 C8H6O2
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SMILES
O=C1OCC2=C1C=CC=C2
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別名
Phthalide
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (745.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 2 mg/mL (14.91 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (18.64 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (18.64 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (279 KB)
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SDS (393 KB)
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- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[2]. Chen LZ, et al. Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo. European journal of medicinal chemistry. 2020 Nov 15;206:112722. [Content Brief]
[3]. Intaraudom C, et al. Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408. Fitoterapia. 2019 Oct;138:104353. [Content Brief]
[4]. Fang X, et al. Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities. Journal of Asian natural products research. 2020 Dec;22(12):1176-1187. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 7.4555 mL | 37.2773 mL | 74.5545 mL | 186.3863 mL |
| 5 mM | 1.4911 mL | 7.4555 mL | 14.9109 mL | 37.2773 mL | |
| 10 mM | 0.7455 mL | 3.7277 mL | 7.4555 mL | 18.6386 mL | |
| DMSO | 15 mM | 0.4970 mL | 2.4852 mL | 4.9703 mL | 12.4258 mL |
| 20 mM | 0.3728 mL | 1.8639 mL | 3.7277 mL | 9.3193 mL | |
| 25 mM | 0.2982 mL | 1.4911 mL | 2.9822 mL | 7.4555 mL | |
| 30 mM | 0.2485 mL | 1.2426 mL | 2.4852 mL | 6.2129 mL | |
| 40 mM | 0.1864 mL | 0.9319 mL | 1.8639 mL | 4.6597 mL | |
| 50 mM | 0.1491 mL | 0.7455 mL | 1.4911 mL | 3.7277 mL | |
| 60 mM | 0.1243 mL | 0.6213 mL | 1.2426 mL | 3.1064 mL | |
| 80 mM | 0.0932 mL | 0.4660 mL | 0.9319 mL | 2.3298 mL | |
| 100 mM | 0.0746 mL | 0.3728 mL | 0.7455 mL | 1.8639 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Phthalide 関連分類
HY-W015820 関連分類
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