Poly(U)
Poly (U) (Polyuridylic acid) is an RNA chain that exists in a disordered extended state at room temperature and serves as a TLR7 ligand. Poly (U) produces distinguishable blocking effects when transported through α-hemolysin nanopores. Poly (U) forms a triple helix with adenosine or adenosine monophosphate, thereby significantly promoting the nucleotide bond condensation reaction between adenosine monophosphate and adenosine, while exerting minimal effects on other nucleosides. When conjugated with cationic lipids, Poly (U) specifically stimulates plasmacytoid dendritic cells to produce type I interferons.
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- CAS 番号: 27416-86-0
- 分子式: (C9H13N2O9P)x
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-101981
Uridine 5'-monophosphateNucleotide Analogue -
HY-101981R
Uridine 5'-monophosphate (Standard)Nucleotide Analogue -
HY-W416291
Polyadenylic acid potassiumPolyribonucleotide -
HY-W008940
Cytidine 5'-diphosphate disodium saltNucleotide -
HY-W008940R
Cytidine 5'-diphosphate disodium salt (Standard)Nucleotide -
HY-141567
Pseudouridine 5'-triphosphateUTP Derivative
生物活性
製品説明
IC50 & Target
[1]|
TLR7 |
体外実験
Poly(U) (10 μg/mL) enabled α-hemolysin nanopores to distinguish 150 nt poly(U) from poly(A) via shorter translocation durations (centered at 1.4 μs/nt and 6 μs/nt) and absence of 55% amplitude blockade shoulders[1].
Poly(U) (30 μg/mL; 24 h) does not induce IFN-α or IL-12p40 production from Flt3L-induced murine bone marrow dendritic cells alone, but does induce both cytokines when mixed with Lipofectamine 2000, with IFN-α levels reaching ~10 ng/mL and IL-12p40 levels reaching ~4 ng/mL after 24 hours[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 27416-86-0
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分子式 (C9H13N2O9P)x
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SMILES
O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O2)NC1=O.[n]
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別名
Polyuridylic acid
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Akeson M, et al. Microsecond time-scale discrimination among polycytidylic acid, polyadenylic acid, and polyuridylic acid as homopolymers or as segments within single RNA molecules[J]. Biophysical journal, 1999, 77(6): 3227-3233. [Content Brief]
[2]. Sugiyama T, et al. Immunoadjuvant effects of polyadenylic: polyuridylic acids through TLR3 and TLR7[J]. International immunology, 2008, 20(1): 1-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Poly(U) 関連分類
HY-131920 関連分類
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