Pralurbactam
Based on 1 Customer Validation
Pralurbactam (FL058) is a β-lactamase (Beta-lactamase) inhibitor. Pralurbactam enhances the antibacterial activity of Imipenem against Mycobacterium abscessus. Pralurbactam reduces the pulmonary bacterial load in neutropenic mice infected with Mycobacterium abscessus. Pralurbactam can be used in research related to infections caused by Mycobacterium abscessus complex, Escherichia coli, and Klebsiella pneumoniae.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.69%
- CAS 番号: 2163782-59-8
- 分子式: C10H18N6O8S
- 分子量:382.35
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Beta-lactamase アイソフォーム固有の製品をすべて表示
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生物活性
Pralurbactam (FL058) (2-4 mg/L; 3-7 days) significantly reduces the MIC of Imipenem (HY-B1369A) against Mycobacterium abscessus subsp. abscessus ATCC 19977 and Mycobacterium abscessus subsp. massiliense CIP 108297[1].
Pralurbactam (4 mg/L; 3-7 days) significantly reduces the MIC50 of Imipenem and increases the proportion of susceptible isolates among 193 clinical MABC isolates (including Mycobacterium abscessus subsp. abscessus and subsp. massiliense)[1].
Pralurbactam (4 mg/L; 72 h) significantly enhances the antibacterial activity of imipenem at 8 mg/L and 32 mg/L against Mycobacterium abscessus subsp. abscessus ATCC 19977 within 72 h[1].
Pralurbactam (4 mg/L; 4-48 h) significantly enhances the intracellular anti-MABC activity of Imipenem against Mycobacterium abscessus subsp. massiliense CIP 108297, clinical isolate A69 and clinical isolate G150 in THP-1 cell-derived macrophages[1].
Combination of Pralurbactam (4 μg/mL) with Meropenem (HY-13678) potently reduces the MIC of NDM-producing Escherichia coli and exhibits partial inhibitory activity against NDM-producing Klebsiella pneumoniae; in contrast, Pralurbactam alone inhibits *Escherichia coli*[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Cmax | T1/2 | AUClast |
|---|---|---|---|---|---|
| Mice[1] | 50 mg/kg | i.v. | 51.4 mg/L | 0.19 h | 23.2 mg·h/L |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (male, 6 weeks old, specific pathogen-free, neutropenic via intraperitoneal cyclophosphamide injection, intranasally infected with Mycobacterium abscessus subsp. massiliense CIP 108297)[1]
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Dosage:100 mg/kg (in combination with 200 mg/kg Imipenem)
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Administration:s.c.; twice daily; 14 days
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Result:Achieved a net reduction of 1.99 log10 CFU in lung bacterial load, which was a 1.01 log10 CFU greater reduction than that achieved with imipenem alone.
化学情報
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CAS 番号 2163782-59-8
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性状 Solid
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分子量 382.35
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分子式 C10H18N6O8S
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Color White to off-white
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SMILES
O=C([C@H](CC1)[N@@](C[C@]1([H])N2O[S](=O)(O)=O)C2=O)NOCCONC(N)=N
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別名
FL058
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 50 mg/mL (130.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Tan Z, et al. FL058, a novel β-lactamase inhibitor, increases the anti-Mycobacterium abscessus activity of imipenem. Int J Antimicrob Agents. 2025;65(2):107414. [Content Brief]
[2]. Huang Z, et al. Pharmacokinetic/pharma-codynamic study of pralurbactam (FL058) combined with meropenem in a neutropenic murine thigh infection model. Front Microbiol. 2024;15:1516979. Published 2024 Dec 17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6154 mL | 13.0770 mL | 26.1540 mL | 65.3851 mL |
| 5 mM | 0.5231 mL | 2.6154 mL | 5.2308 mL | 13.0770 mL | |
| 10 mM | 0.2615 mL | 1.3077 mL | 2.6154 mL | 6.5385 mL | |
| 15 mM | 0.1744 mL | 0.8718 mL | 1.7436 mL | 4.3590 mL | |
| 20 mM | 0.1308 mL | 0.6539 mL | 1.3077 mL | 3.2693 mL | |
| 25 mM | 0.1046 mL | 0.5231 mL | 1.0462 mL | 2.6154 mL | |
| 30 mM | 0.0872 mL | 0.4359 mL | 0.8718 mL | 2.1795 mL | |
| 40 mM | 0.0654 mL | 0.3269 mL | 0.6539 mL | 1.6346 mL | |
| 50 mM | 0.0523 mL | 0.2615 mL | 0.5231 mL | 1.3077 mL | |
| 60 mM | 0.0436 mL | 0.2180 mL | 0.4359 mL | 1.0898 mL | |
| 80 mM | 0.0327 mL | 0.1635 mL | 0.3269 mL | 0.8173 mL | |
| 100 mM | 0.0262 mL | 0.1308 mL | 0.2615 mL | 0.6539 mL |
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