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製品番号: HY-11039

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PU24FCl

PU24FCl is a specific inhibitor of Hsp90. PU24FCl exhibits wide-ranging anti-cancer activities. PU24FCl accumulates in tumors while being rapidly cleared from normal tissue.

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CAS 番号: 422508-46-1
分子式: C₂₀H₂₁ClFN₅O₃
分子量:433.86

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

PU24FCl 構造式

CAS 番号: 422508-46-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

PU24FCl is a specific inhibitor of Hsp90. PU24FCl exhibits wide-ranging anti-cancer activities. PU24FCl accumulates in tumors while being rapidly cleared from normal tissue^[1].

IC₅₀ & Target

^[1]

HSP90

HSP アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	GI₅₀	3.9 μM Compound: 8	Cellular activity against human colon tumor cell line, HCT116 Cellular activity against human colon tumor cell line, HCT116	[PMID: 14698151]
MCF7	IC₅₀	1.2 μM Compound: PUC24FCI	Antiproliferative activity against human MCF7 cells by MTS assay Antiproliferative activity against human MCF7 cells by MTS assay	[PMID: 17488003]
MCF7	IC₅₀	1.7 μM Compound: PUC24FCI	Inhibition of human recombinant HSP90 in MCF7 cells assessed as Her2 degradation Inhibition of human recombinant HSP90 in MCF7 cells assessed as Her2 degradation	[PMID: 17488003]
MCF7	IC₅₀	2.5 μM Compound: PUC24FCI	Binding affinity to human recombinant HSP90 in MCF7 cell lysates assessed as inhibition of biotinylated-geldanamycin binding Binding affinity to human recombinant HSP90 in MCF7 cell lysates assessed as inhibition of biotinylated-geldanamycin binding	[PMID: 17488003]
MCF7	IC₅₀	7 μM Compound: PUC24FCI	Selectivity for HSP90 in MCF7 cells over HSP90 in NDF cells Selectivity for HSP90 in MCF7 cells over HSP90 in NDF cells	[PMID: 17488003]
MDA-MB-468	EC₅₀	0.23 μM Compound: 4	Effective concentration against heat shock protein HSP90-alpha in MDA-MB-468 cells Effective concentration against heat shock protein HSP90-alpha in MDA-MB-468 cells	[PMID: 15828828]
SK-BR-3	IC₅₀	0.66 μM Compound: PU24FCl	Displacement of GM-cy3B from Hsp90 in human SKBR3 cells after 24 hrs by fluorescence polarization assay Displacement of GM-cy3B from Hsp90 in human SKBR3 cells after 24 hrs by fluorescence polarization assay	[PMID: 24548207]
SK-BR-3	IC₅₀	1.8 μM Compound: 4	Inhibitory concentration against SKBr3 cell line Inhibitory concentration against SKBr3 cell line	[PMID: 15828828]
SK-BR-3	IC₅₀	2 μM Compound: PU24FCl	Inhibition of Hsp70 in human SKBR3 cells assessed as HER2 protein degradation by Western blotting analysis Inhibition of Hsp70 in human SKBR3 cells assessed as HER2 protein degradation by Western blotting analysis	[PMID: 24548207]
SK-BR-3	IC₅₀	2.5 μM Compound: PU24FCl	Inhibition of Hsp70 in human SKBR3 cells assessed as RAF1 protein degradation by Western blotting analysis Inhibition of Hsp70 in human SKBR3 cells assessed as RAF1 protein degradation by Western blotting analysis	[PMID: 24548207]
SK-BR-3	IC₅₀	2.9 μM Compound: PU24FCl	Growth inhibition of human SKBR3 cells after 72 hrs by Alamar Blue assay Growth inhibition of human SKBR3 cells after 72 hrs by Alamar Blue assay	[PMID: 24548207]

化学情報

CAS 番号 422508-46-1
分子量 433.86
分子式 C₂₀H₂₁ClFN₅O₃
SMILES

FC1=NC2=C(N=C(CC3=CC(OC)=C(C(OC)=C3Cl)OC)N2CCCC#C)C(N)=N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Vilenchik M, et, al. Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90. Chem Biol. 2004 Jun;11(6):787-97. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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PU24FCl

HSP アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

Cellular Effect

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

PU24FCl 関連分類

HY-11039 関連分類

Bioz

Keywords

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