Ractopamine
Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with Kd value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC50 of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 97825-25-7
- 分子式: C18H23NO3
- 分子量:301.38
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Adrenergic Receptor アイソフォーム固有の製品をすべて表示
More
生物活性
|
pig β1AR ~25 nM (Kd) |
pig β2AR ~25 nM (Kd) |
mTAAR1 16 μM (EC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
0.33 μM
Compound: (rac)-3
|
Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting
Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting
|
[PMID: 19245211] |
Ractopamine (50 nM-100 μM) acts as a full agonist of mouse trace amine-associated receptor 1 (mTAAR1) in Xenopus laevis oocytes coexpressing hCFTR and mTAAR1, with an EC50 of 16 μM, via a cAMP-dependent pathway[1].
Ractopamine increases protein accumulation and synthesis in postfusion ELC5 myotubes in a concentration-dependent manner[3].
Ractopamine shows Kd value of ~25 nM for pig β1AR and β2AR[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ractopamine (5-20 mg/kg; p.o.; daily; 48 days) administered in the diet of finishing swine linearly improves average daily gain, increases carcass weight and loin eye are[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:crossbred Camborough 25 × AGPIC 337 (170 barrows, 170 gilts, average initial body weight 107.3 kg)[2]
-
Dosage:5 mg/kg; 10 mg/kg
-
Administration:oral; divided into 3 daily portions; 28 days
-
Result:Increased the average percentage of pigs nosing pen mates to 6.73% (vs control 5.62%) at 5 mg/kg.
Reduced the average percentage of pigs playing to 0.06% (vs control 0.26%) at 5 mg/kg.
Increased the average percentage of pigs drinking water to 2.06% (vs control 1.58%) at 5 mg/kg.
Increased the average percentage of pigs standing to 1.39% (vs control 0.85%) at 10 mg/kg.
Increased serum CK-MB concentration to 4361 U/L (vs control 2341 U/L) and serum CK-total concentration to 12,436 U/L (vs control 5811 U/L) at 5 mg/kg.
Increased serum CK-MB concentration to 4510 U/L (vs control 2341 U/L) and serum CK-total concentration to 10,707 U/L (vs control 5811 U/L) at 10 mg/kg.
Showed no significant effect on overall pig behavior classification, skin/carcass lesions, blood cortisol or lactate concentrations.
化学情報
-
CAS 番号 97825-25-7
-
分子量 301.38
-
分子式 C18H23NO3
-
SMILES
OC(CNC(C)CCC1=CC=C(O)C=C1)C2=CC=C(O)C=C2
-
別名
LY031537 free base
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Liu X, et al. Ractopamine, a livestock feed additive, is a full agonist at trace amine-associated receptor 1. J Pharmacol Exp Ther. 2014;350(1):124-129. [Content Brief]
[2]. Athayde N B, et al. Stress susceptibility in pigs supplemented with ractopamine[J]. Journal of Animal Science, 2013, 91(9): 4180-4187. [Content Brief]
[3]. Anderson P T, et al. Ractopamine increases total and myofibrillar protein synthesis in cultured rat myotubes[J]. The Journal of nutrition, 1990, 120(12): 1677-1683. [Content Brief]
[4]. Stites CR, et al. The effect of ractopamine hydrochloride on the carcass cutting yields of finishing swine. J Anim Sci. 1991;69(8):3094-3101. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Ractopamine 関連分類
HY-113781 関連分類
Powered by Bioz