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United States

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製品番号: HY-118285

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Ro4491533

Ro4491533 is a selective, negative allosteric mGluR2/3 receptor modulator that is equally effective on both subtypes. Ro4491533 can completely block glutamate-induced calcium mobilization and glutamate-induced [35S]GTPγS binding accumulation. Ro4491533 has good pharmacokinetic properties in mice and rats, high oral bioavailability, and can pass through the blood-brain barrier. Ro4491533 can also reverse the motor inhibition effect of LY379268 in mice and show antidepressant activity in the forced swim test and tail suspension test.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 579482-31-8
分子式: C₂₄H₂₀F₃N₃O
分子量:423.43

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Ro4491533 構造式

CAS 番号: 579482-31-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

mGluR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	<0.01 μM Compound: 7am	Antagonist activity at rat mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current Antagonist activity at rat mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current	[PMID: 20971004]
CHO	IC₅₀	<0.01 μM Compound: 7am	Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK current Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK current	[PMID: 20971004]
CHO	IC₅₀	0.003 μM Compound: 7am	Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP production Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP production	[PMID: 20971004]
CHO	IC₅₀	0.014 μM Compound: 7am	Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current	[PMID: 20971004]

化学情報

CAS 番号 579482-31-8
分子量 423.43
分子式 C₂₄H₂₀F₃N₃O
SMILES

O=C1NC2=CC(C(F)(F)F)=C(C=C2N=C(C1)C3=CC=CC(C4=CC(C)=NC(C)=C4)=C3)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Characterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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