Ruzotolimod
Based on 1 Customer Validation
Ruzotolimod (RO7020531) is an orally active TLR7 agonist. Ruzotolimod inhibits WHV viral replication and, in combination with RO-7049389 (HY-145579), inhibits AAV-HBV viral load. Ruzotolimod can be used to study infection with COVID-19 or SARS-CoV-2.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.92%
- CAS 番号: 1948241-60-8
- 分子式: C14H18N4O5S
- 分子量:354.38
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
TLR7[1]
体内実験
Ruzotolimod (30-120 mg/kg; p.o.; every other day; 24-week monotherapy or 14-week combination treatment with Entecavir (HY-13623)) can inhibit viral replication, cause the disappearance of viral antigens, and induce seroconversion in some woodchucks, and also induce a sustained antiviral response in some animals in the woodchuck model infected with woodchuck hepatitis virus (WHV)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1948241-60-8
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性状 Solid
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分子量 354.38
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分子式 C14H18N4O5S
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Color Off-white to light yellow
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SMILES
O=C1N([C@]([C@@H](C2)O)([H])O[C@]2([H])[C@H](CC)OC(C)=O)C3=NC(N)=NC=C3S1
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別名
RO7020531; RG7854
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 125 mg/mL (352.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Qingyan BO, et al. Method of treating virus infection using a tlr7 agonist. Patent WO2021130195A1.
[2]. Jiang Q, et al. Using exploratory pharmacokinetic and pharmacodynamic analyses to predict the probability of flu‐like symptoms in healthy volunteers and patients with chronic hepatitis B treated with the toll‐like receptor 7 agonist ruzotolimod[J]. Clinical and Translational Science, 2024, 17(8): e13896. [Content Brief]
[4]. Wildum S, et al. Toll-Like Receptor 7 Agonist RG7854 Mediates Therapeutic Efficacy and Seroconversion in Woodchucks With Chronic Hepatitis B. Front Immunol. 2022 May 23;13:884113. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8218 mL | 14.1091 mL | 28.2183 mL | 70.5457 mL |
| 5 mM | 0.5644 mL | 2.8218 mL | 5.6437 mL | 14.1091 mL | |
| 10 mM | 0.2822 mL | 1.4109 mL | 2.8218 mL | 7.0546 mL | |
| 15 mM | 0.1881 mL | 0.9406 mL | 1.8812 mL | 4.7030 mL | |
| 20 mM | 0.1411 mL | 0.7055 mL | 1.4109 mL | 3.5273 mL | |
| 25 mM | 0.1129 mL | 0.5644 mL | 1.1287 mL | 2.8218 mL | |
| 30 mM | 0.0941 mL | 0.4703 mL | 0.9406 mL | 2.3515 mL | |
| 40 mM | 0.0705 mL | 0.3527 mL | 0.7055 mL | 1.7636 mL | |
| 50 mM | 0.0564 mL | 0.2822 mL | 0.5644 mL | 1.4109 mL | |
| 60 mM | 0.0470 mL | 0.2352 mL | 0.4703 mL | 1.1758 mL | |
| 80 mM | 0.0353 mL | 0.1764 mL | 0.3527 mL | 0.8818 mL | |
| 100 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.7055 mL |
Ruzotolimod 関連分類
HY-145592 関連分類
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