(S)-C33
Based on 1 Customer Validation
(S)-C33 is a potent and selective PDE9 (phosphodiesterase-9) inhibitor, with an IC50 of 11 nM. (S)-C33 can be used for central nervous system diseases and diabetes research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.46%
- CAS 番号: 2066488-39-7
- 分子式: C18H20ClN5O
- 分子量:357.84
-
保管条件:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
PDE9A 11 nM (IC50) |
PDE5A1 366 nM (IC50) |
PDE1B 554 nM (IC50) |
PDE4D2 1.3 μM (IC50) |
PDE10A1 2.3 μM (IC50) |
PDE2A 2.4 μM (IC50) |
(S)-C33 shows the T1/2 values of 105 and 54 minutes in human and mouse microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 2066488-39-7
-
性状 Solid
-
分子量 357.84
-
分子式 C18H20ClN5O
-
Color White to off-white
-
SMILES
O=C1C2=C(N(C3CCCC3)N=C2)N=C(N[C@H](C4=CC=C(Cl)C=C4)C)N1
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
DMSO : 100 mg/mL (279.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (272 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7945 mL | 13.9727 mL | 27.9455 mL | 69.8636 mL |
| 5 mM | 0.5589 mL | 2.7945 mL | 5.5891 mL | 13.9727 mL | |
| 10 mM | 0.2795 mL | 1.3973 mL | 2.7945 mL | 6.9864 mL | |
| 15 mM | 0.1863 mL | 0.9315 mL | 1.8630 mL | 4.6576 mL | |
| 20 mM | 0.1397 mL | 0.6986 mL | 1.3973 mL | 3.4932 mL | |
| 25 mM | 0.1118 mL | 0.5589 mL | 1.1178 mL | 2.7945 mL | |
| 30 mM | 0.0932 mL | 0.4658 mL | 0.9315 mL | 2.3288 mL | |
| 40 mM | 0.0699 mL | 0.3493 mL | 0.6986 mL | 1.7466 mL | |
| 50 mM | 0.0559 mL | 0.2795 mL | 0.5589 mL | 1.3973 mL | |
| 60 mM | 0.0466 mL | 0.2329 mL | 0.4658 mL | 1.1644 mL | |
| 80 mM | 0.0349 mL | 0.1747 mL | 0.3493 mL | 0.8733 mL | |
| 100 mM | 0.0279 mL | 0.1397 mL | 0.2795 mL | 0.6986 mL |
(S)-C33 関連分類
HY-124775 関連分類
Powered by Bioz