Salvicine
Salvicine is a DNA topoisomerase II inhibitor (IC50=3 μM). Salvicine increases the interaction between DNA and Topo II by interacting with the ATPase domain, inhibiting DNA degradation and ATP hydrolysis. Salvicine has anticancer activities, including inhibiting Topo II, causing DNA damage, overcoming multidrug resistance, and inhibiting tumor cell adhesion.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 240423-23-8
- 分子式: C20H26O4
- 分子量:330.42
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Topoisomerase アイソフォーム固有の製品をすべて表示
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生物活性
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Topoisomerase II 3 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
3.57 μM
Compound: 4
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In vitro cytotoxic activity against HL-60 human leukemia cell line by MTT assay (microculture terazolium colorimetric)
In vitro cytotoxic activity against HL-60 human leukemia cell line by MTT assay (microculture terazolium colorimetric)
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[PMID: 10509925] |
| P388 | IC50 |
3.49 μM
Compound: 4
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In vitro cytotoxic activity against P388 mouse leukemia cell line by MTT assay (microculture terazolium colorimetric)
In vitro cytotoxic activity against P388 mouse leukemia cell line by MTT assay (microculture terazolium colorimetric)
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[PMID: 10509925] |
| SGC-7901 | IC50 |
1.84 μM
Compound: 4
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In vitro cytotoxic activity against SGC-7901 stomach cancer solid tumor cell line by MTT assay (microculture terazolium colorimetric)
In vitro cytotoxic activity against SGC-7901 stomach cancer solid tumor cell line by MTT assay (microculture terazolium colorimetric)
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[PMID: 10509925] |
| SPC-A4 | IC50 |
2.46 μM
Compound: 4
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In vitro cytotoxic activity against SPC-A4 lung cancer solid tumor cell line by MTT assay (microculture terazolium colorimetric)
In vitro cytotoxic activity against SPC-A4 lung cancer solid tumor cell line by MTT assay (microculture terazolium colorimetric)
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[PMID: 10509925] |
化学情報
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CAS 番号 240423-23-8
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分子量 330.42
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分子式 C20H26O4
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SMILES
O=C1C(C(C(C)C)=CC2=C1C(CCC(C(C)(C)O)O)=C(C)C=C2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Dey D, et al. Investigating the anticancer potential of salvicine as a modulator of topoisomerase II and ROS signaling cascade[J]. Frontiers in oncology, 2022, 12: 899009. [Content Brief]
[2]. Meng L, et al. Salvicine, a novel DNA topoisomerase II inhibitor, exerting its effects by trapping enzyme-DNA cleavage complexes[J]. Biochemical pharmacology, 2001, 62(6): 733-741. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Salvicine 関連分類
HY-W715630 関連分類
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