SB-209247
Based on 1 publication(s) in Google Scholar
SB-209247 is a selective, high affinity and orally active leukotriene B4 (LTB4) receptor antagonist with a Ki of 0.78 nM. SB-209247 blocks LTB4-induced Ca2+ mobilization with an IC50 of 6.6 nM. SB-209247 shows a potent anti-inflammatory activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.33%
- CAS 番号: 154413-61-3
- 分子式: C23H19Cl2NO3S
- 分子量:460.37
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 SB-209247
MoreLeukotriene Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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LTB4 0.78 nM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RBL-1 | IC50 |
8200 nM
Compound: 3
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Concentration required to inhibit RBL-1 supernatant 5-lipoxygenase
Concentration required to inhibit RBL-1 supernatant 5-lipoxygenase
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[PMID: 8809171] |
SB-209247 (Compound 3) demonstrates a high degree of selectivity for the LTB4 receptor. SB-209247 competes with [3H]-fMLP and [3H]LTD4 in respective receptor binding assays with IC50 values of 3250 nM and 16800 nM and with another 14 ligands with IC50 values greater than 10000 nM. Functional activity at the cellular level is demonstrated in human polymorphonuclear leukocytes (PMNs) by blocking the LTB4-induced Ca2+ mobilization and LTB4-induced degranulation with IC50 values of 6.6 nM and 53 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 154413-61-3
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性状 Solid
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分子量 460.37
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分子式 C23H19Cl2NO3S
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Color White to off-white
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SMILES
O=C(O)/C=C/C1=NC(CSC2=C(Cl)C=CC=C2Cl)=CC=C1OCCC3=CC=CC=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Leukoc Biol
Caging giants: Characterizing the molecular mechanisms of neutrophil swarming against Candida albicans hyphae. [Abstract]2025 Jun 6:qiaf082. PMID: 40476443
純度とドキュメンテーション
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データシート (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SB-209247 関連分類
HY-112741 関連分類
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