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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
製品番号: HY-N1393S
別名: NSC 3778-13C6; O-Methylsalicylic acid-13C6; Salicylic acid methyl ether-13C6
製品番号: HY-N1393S1
CAS 番号: 96739-36-5
別名: NSC 3778-d3; O-Methylsalicylic acid-d3; Salicylic acid methyl ether-d3
2-Methoxybenzoic acid (NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether)-d3 is deuterium-labeled 2-Methoxybenzoic acid (HY-N1393). 2-Methoxybenzoic acid is a natural compound with potential salicylate-like effect. 2-Methoxybenzoic acid inhibits carbonic anhydrase activity, elevates intraplatelet cyclic guanosine monophosphate level, and suppresses cytosolic phospholipase A2 phosphorylation. 2-Methoxybenzoic acid suppresses platelet reactivity, including decreased spreading, retraction, and aggregation in platelets. 2-Methoxybenzoic acid ameliorates arterial thrombosis in a dose-dependent manner without affecting normal hemostasis in mice. 2-Methoxybenzoic acid can be used for the research of arterial thrombosis .
製品番号: HY-N1408
CAS 番号: 22255-22-7
別名: trans-trismethoxy Resveratrol; (E)-Resveratrol trimethyl ether; trans-3,5,4'-Trimethoxystilbene
製品番号: HY-N2282
CAS 番号: 91653-50-8
別名: Zingiberensis newsaponin
製品番号: HY-N6801R
CAS 番号: 23282-20-4
Category:
製品番号: HY-P10887
CAS 番号: 2988012-71-9
別名: AV-001
Target:
Tie ANGPTL SARS-CoV Aquaporin TNF Receptor PAI-1 CXCR P-selectin
製品番号: HY-P11581
Target:
NOD-like Receptor (NLR) Interleukin Related Caspase Amyloid-β Tau Protein α-synuclein Pyroptosis
研究分野:
製品番号: HY-P11582
製品番号: HY-P4277
CAS 番号: 149438-56-2
別名: DiFMOC-G
N,S-Bis-Fmoc-Glutathione (DiFMOC-G) is a GLO2 selective inhibitor with a KA of 0.75 μM against bovine liver GLO2. N,S-Bis-Fmoc-Glutathione competitively inhibits the hydrolysis of S-d-lactoylglutathione to glutathione and D-lactate, leading to intracellular SLG accumulation and protein D-lactylation. N,S-Bis-Fmoc-Glutathione reduces serum inflammatory cytokines and interferons, improves survival in acute inflammation/cytokine storm and TNBS colitis models, and decreases senescence-associated secretory phenotype, immune activation, and inflammation in aging and autoimmune models. N,S-Bis-Fmoc-Glutathione can be used in research on autoimmune diseases and inflammation-related diseases .
製品番号: HY-P5226
CAS 番号: 936544-53-5
Palmitoyl tripeptide-8 is an immunomodulatory peptide and neurotransmitter inhibitory peptide. Palmitoyl tripeptide-8 inhibits the activation of the NF-κB pathway and the production of pro-inflammatory cytokines (IL-8, IL-6, and TNF-α). Palmitoyl tripeptide-8 activates the cutaneous opioid system and reduces CGRP release. Palmitoyl tripeptide-8 decreases the number of dilated capillaries, the size of dilated vessels, and the degree of edema in skin explants treated with Substance P (HY-P0201). Palmitoyl tripeptide-8 is used as an active ingredient in cosmetics for sensitive skin. Palmitoyl tripeptide-8 is utilized in research related to sensitive skin .
製品番号: HY-P990208
Target:
製品番号: HY-P992583
研究分野:
Anti-Mouse ApoE Antibody (HJ6.3) is an IgG1 κ monoclonal antibody targeting mouse ApoE that can cross the blood-brain barrier and binds to brain plaques and CAA. Anti-Mouse ApoE Antibody (HJ6.3) reduces cortical activated microglial immunoreactivity, decreases small amyloid deposits, binds astrocytes, immunoprecipitates cortical apoE, potentially blocks apoE-Aβ interactions, alleviates impaired Aβ clearance, recruits/activates microglia, reduces IFN-γ/IL-1α, and inhibits Aβ aggregation/amyloid accumulation. Anti-Mouse ApoE Antibody (HJ6.3) can be used for research on Alzheimer's disease .
製品番号: HY-P99292
CAS 番号: 326859-36-3
別名: HuZAF; Anti-Human IFNG Recombinant Antibody
Target:
研究分野:
製品番号: HY-W014180
CAS 番号: 39145-52-3
Category:
Ketones, Aldehydes, Acids Animal Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
製品番号: HY-W017540R
CAS 番号: 35404-50-3
Target:
Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer .
製品番号: HY-W072962
CAS 番号: 723754-14-1
Target:
研究分野:
WX2-43 is a PRMT5-KLF4 inhibitor (Kd of 11.0 nM). WX2-43 binds to the region between amino acids L400-M500 on PRMT5. WX2-43 efficiently intercepts the interaction between KLF4 and PRMT5, and blocks KLF4 methylation. WX2-43 decreases p21 levels and increases Bax levels. WX2-43 suppresses triple negative breast tumor progression. WX2-43 can be used in the research of triple-negative breast cancer and colorectal cancer .
製品番号: HY-W095697
CAS 番号: 2497-02-1
Target:
製品番号: HY-W160358
CAS 番号: 3809-32-3
製品番号: HY-Y0682AR
CAS 番号: 6381-92-6
別名: EDTA disodium dihydrate (Standard)
Ethylenediaminetetraacetic acid (disodium dihydrate) (Standard) is the analytical standard of Ethylenediaminetetraacetic acid (disodium dihydrate). This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research [4] .
製品番号: HY-101396R
CAS 番号: 582323-16-8
Target:
研究分野:
ICA-069673 (Standard) is the analytical standard of ICA-069673 (HY-101396). This product is intended for research and analytical applications. ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
