Pegevongitide
Based on 1 Customer Validation
Pegevongitide (AV-001) is a Tie2 agonist. Pegevongitide resists the increased endothelial cell permeability induced by SARS-CoV-2 infection. Pegevongitide activates the angiogenin (angiogenin)/Tie2 signaling pathway. Pegevongitide reduces perivascular space dilation and upregulates perivascular Aquaporin-4 expression. Pegevongitide decreases the expression of TNF-α, PAI-1, CXCL9 and P-selectin, improves white matter integrity, enhances cognitive function and exerts neuroprotective effects. Pegevongitide improves white matter integrity in middle-aged rats with vascular dementia induced by multiple microinfarctions. Pegevongitide can be used in related research on diseases such as COVID-19 and vascular dementia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.60%
- CAS 番号: 2988012-71-9
- 分子量:14600 (Approximately)
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
Tie2 |
TNF-α |
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male, middle-aged, 10-12 months, multiple microinfarction-induced vascular dementia model)[2]
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Dosage:1 μg/kg
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Administration:i.p.; once daily; 14 days
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Result:Significantly improved white matter integrity in the corpus callosum (reduced rarefaction and vacuolation) compared to untreated multiple microinfarction rats.
Significantly attenuated demyelination in the corpus callosum and striatum compared to untreated multiple microinfarction rats.
Significantly reduced perivascular space dilation in the cortex and striatum compared to untreated multiple microinfarction rats.
Significantly increased perivascular Aquaporin-4 expression in the cortex compared to untreated multiple microinfarction rats.
Significantly improved glymphatic function: increased expression of 500 kD FITC dextran at 30 minutes and 3 hours post-infusion, increased expression of 3 kD Tetramethylrhodamine dextran at 30 minutes post-infusion, and significantly increased clearance of both tracers by 6 hours post-infusion compared to untreated multiple microinfarction rats.
Significantly decreased cerebrospinal fluid expression of inflammatory factors (tumor necrosis factor-α, chemokine ligand 9) and anti-angiogenic factors (endostatin, plasminogen activator inhibitor-1, P-selectin) compared to untreated multiple microinfarction rats.
Significantly reduced brain tissue mRNA expression of endostatin, thrombin, tumor necrosis factor-α, interleukin-6, plasminogen activator inhibitor-1, and chemokine ligand 9 compared to untreated multiple microinfarction rats.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
化学情報
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CAS 番号 2988012-71-9
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性状 Solid
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分子量 14600 (Approximately)
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Color White to off-white
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別名
AV-001
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
H2O : ≥ 10 mg/mL
* "≥" means soluble, but saturation unknown.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (284 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Pegevongitide 関連分類
HY-P10887 関連分類
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Keywords
- Pegevongitide
- 2988012-71-9
- AV-001
- AV001
- AV 001
- Tie
- ANGPTL
- SARS-CoV
- Aquaporin
- TNF Receptor
- PAI-1
- CXCR
- P-selectin
- Angiopoietin receptor
- Angiopoietin-like protein
- SARS coronavirus
- AQP
- Tumor Necrosis Factor Receptor
- TNFR
- Plasminogen activator inhibitor-1
- CXC chemokine receptors
- C-X-C motif chemokine receptors
- CD62
- sepsis
- Tie2
- influenza
- vascular dementia
- angiopoietin/Tie2 signaling pathway
- middle-aged rats
- SARS-CoV-2
- Aquaporin-4
- endothelial cell
- Alzheimer's disease
- Inhibitor
- inhibitor
- inhibit