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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
製品番号: HY-13676S1
製品番号: HY-139804
CAS 番号: 1297262-16-8
CTK7A is a curcumin derivative with anticancer activity by inhibiting the HAT activity of p300 and reducing the autoacetylation of p300, thereby affecting its interaction with HIF-1α. The inhibition of CTK7A leads to decreased HIF-1α accumulation and activity, which can be used for cancer research .
製品番号: HY-144273
研究分野:
IDO1-IN-13 (compound 27a) is a potent IDO1 inhibitor with an IC50 of 61.6 nM. IDO1-IN-13 has cellular IDO1 inhibition (HeLa EC50= 30 nM). IDO1-IN-13 decreases 51% of the kyn/trp ratio in SK-OV-3 xenograft tumor tissues .
製品番号: HY-14939A
CAS 番号: 279253-83-7
Target:
研究分野:
Vapitadine hydrochloride (Compound 3a) is a selective, orally active and nonsedating antihistamine agent, which exhibits a good binding affinity with human cloned histamine H1 receptor with a Ki of 19 nM. Vapitadine hydrochloride decreases the histamine-induced lethality (ED50 is 0.056-1.2 mg/kg), antagonizes the cutaneous reactions to histamine (ED50 is 0.51-1.4 mg/kg) in rats .
製品番号: HY-149670
CAS 番号: 3017222-33-9
Target:
研究分野:
Ferroptosis-IN-3 (Compound 25) is a ferroptosis inhibitor. Ferroptosis-IN-3 inhibits RSL3-induced ferroptosis (EC50: 8.6 nM in HT-1080 cells). Ferroptosis-IN-3 scavenges DPPH and ABTS radicals (EC50: 3.94 and 6.3 μM respectively). Ferroptosis-IN-3 decreases lipid peroxidation .
Target:
研究分野:
HIF-1/2α-IN-2 is an inhibitor of HIF-1/2α. HIF-1/2α-IN-2 decrease HIF-1/2α levels and induces iron starvation response by targeting Iron Sulfur Cluster Assembly 2 (ISCA2) .
製品番号: HY-15297R
CAS 番号: 81840-15-5
別名: OPC-8212 (Standard)
Vesnarinone (Standard) is the analytical standard of Vesnarinone. This product is intended for research and analytical applications. Vesnarinone (OPC-8212) is an orally active phosphodiesterase 3 (PDE3) inhibitor. Vesnarinone can increase in calcium flux and decrease in potassium flux. Vesnarinone shows dose-dependent positive inotropic activity. Vesnarinone can be used in heart failure research .
製品番号: HY-153762
CAS 番号: 2725863-08-9
Target:
研究分野:
COX-2-IN-32 (Compound 2f) is an iNOS and COX-2 inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC50: 11.2 μM) .
製品番号: HY-165555
CAS 番号: 904576-65-4
MMV665917 is an orally active piperazine derivative with anti-Cryptosporidium parvum activity with an EC90 of 15 μM. MMV665917 significantly reduces the parasite load in a porcine model infected with C. hominis, decreases ovarian excretion, alleviates diarrhea symptoms and reduces intestinal mucosal damage. MMV665917 can be used for research on Cryptosporidium parvum disease .
製品番号: HY-168885
CAS 番号: 2923210-02-8
ZSH-512 is a potent RARγ inhibitor. ZSH-512 shows antiproliferation activity. ZSH-512 induces apoptosis. ZSH-512 decreases CD133, NANOG, SOX2, and EPCAM protein expression. ZSH-512 shows anticancer activity. ZSH-512 has the potential for the research of colorectal cancer .
製品番号: HY-177647
CAS 番号: 2411937-33-0
別名: BIIB-101; ION-464
Target:
研究分野:
Movronersen (BIIB-101; ION-464) is an antisense oligonucleotide that targets SNCA; it promotes the degradation of SNCA mRNA and downregulates the synthesis of α-synuclein. By reducing the production of α-synuclein, Movronersen decreases protein misfolding and aggregation, thereby interfering with the pathological progression of synucleinopathies. Movronersen is used in research related to multiple system atrophy and associated disorders .
製品番号: HY-177647A
別名: BIIB-101 sodium; ION-464 sodium
Target:
研究分野:
Movronersen sodium (BIIB-101 sodium; ION-464 sodium) is an antisense oligonucleotide that targets SNCA; it promotes the degradation of SNCA mRNA and downregulates the synthesis of α-synuclein. By reducing the production of α-synuclein, Movronersen sodium decreases protein misfolding and aggregation, thereby interfering with the pathological progression of synucleinopathies. Movronersen sodium is used in research related to multiple system atrophy and associated disorders .
製品番号: HY-177743
CAS 番号: 2980502-40-5
Target:
研究分野:
TR-213 is a potent molecular glue degrader that targets Cyclin K (CDK). TR-213 induces 91% and 56% decrease in CDK12 and Cyclin at 1 μM. TR-213 can inhibit RNA polymerase II activity and regulates alternative polyadenylation (APA) activity. TR-213 can be used for the research of cancer .
製品番号: HY-182479
CAS 番号: 130613-18-2
Target:
研究分野:
MDL 100748 is an NMDA receptor glycine site antagonist. MDL 100748 modulates NMDA receptor function by acting at the strychnine-insensitive glycine site, which is required for NMDA receptor activation alongside glutamate. MDL 100748 decreases response rates in operant conditioning sessions in phencyclidin (PCP)-trained rats. MDL 100748 can be used for reserach on dementias and schizophrenia .
製品番号: HY-186294
CAS 番号: 1810867-99-2
Target:
研究分野:
Methyl-celastrol is a Celastrol (HY-13067) derivative and triterpenoid compound. Methyl-celastrol exists in Celastrus hypoleucus (Oliv) Warb f argutior Loes and other Celastraceae plants. Methyl-celastrol induces weight loss, reduces body fat, decreases food intake and improves glucose homeostasis. Methyl-celastrol is applicable to obesity-related research .
製品番号: HY-188065
CAS 番号: 773839-36-4
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研究分野:
LNP 509 is a selective I1 imidazoline receptor ligand with a bovine pKi value of 6.27. LNP 509 exists mainly in the form of a more stable imine tautomer. Intracisternal administration of LNP 509 in anesthetized rabbits induces a dose-dependent decrease in mean arterial blood pressure. LNP 509 can be used in hypertension-related research .
製品番号: HY-19070
CAS 番号: 115642-84-7
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研究分野:
BRL-52656 is a blood-brain barrier (BBB)-penetrable KOR receptor agonist that exhibits a biphasic effect. At low doses, BRL-52656 decreases blood pressure, whereas high doses have the opposite effect in spontaneously hypertensive rats. Additionally, BRL-52656 induces water diuresis by inhibiting the secretion of vasopressin (AVP) .
製品番号: HY-19731
CAS 番号: 522606-67-3
別名: MiR-544 Inhibitor 1
SID 3712249 (MiR-544 Inhibitor 1) is a miR-544 biogenesis inhibitor. SID 3712249 binds directly to the precursor miRNA. SID 3712249 blocks production of the mature microRNA and decreases miR-544, HIF-1α, and ATM transcripts. SID 3712249 can be used in the research of cancers, such as breast cancer .
製品番号: HY-34469
CAS 番号: 138642-62-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
