SID 24785302
SID 24785302 is a hexokinase inhibitor with antiparasitic activity. SID 24785302 exhibits activity against T. brucei and Leishmania. SID 24785302 can be used for the research of mitochondrial DNA disorders and parasitic infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 378197-09-2
- 分子式: C14H12N2O3S2
- 分子量:320.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
体外実験
SID 24785302 (10 μM; 2 h) potently and selectively inhibits bacterially expressed Trypanosoma brucei hexokinase 1 with an IC50 of 4.2 μM, while causing minimal inhibition of human glucokinase at 10 μM[3].
SID 24785302 (3 days) potently inhibits the growth of Trypanosoma brucei bloodstream form parasites with an EC50 of 0.042 μM[3].
SID 24785302 (10 μM; 2 days) moderately inhibits the growth of Trypanosoma brucei procyclic form parasites, causing 47% inhibition at 10 μM[3].
SID 24785302 (44 h) inhibits the growth of Leishmania major promastigotes with an EC50 of 1.9 μM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 378197-09-2
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分子量 320.39
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分子式 C14H12N2O3S2
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SMILES
O=C(CC1=CSC(N2SC3=C(C2=O)C=CC=C3)=N1)OCC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Antonella SPINAZZOLA, et al. Compounds for treating mitochondrial dna disorders. WO2023089313A1.
[2]. Heneberg P. Redox Regulation of Hexokinases. Antioxid Redox Signal. 2019 Jan 20;30(3):415-442. [Content Brief]
[3]. Sharlow ER, et al. A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity. PLoS Negl Trop Dis. 2010;4(4):e659. Published 2010 Apr 13. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SID 24785302 関連分類
HY-169728 関連分類
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Keywords
- SID 24785302
- 378197-09-2
- SID24785302
- SID-24785302
- Hexokinase
- Parasite
- mitochondrial DNA disorders
- hexokinase inhibitor
- T. brucei blood stage parasites
- Trypanosoma brucei procyclic form (29-13)
- CYP2D6
- Trypanosoma brucei bloodstream form (90-13)
- Leishmania promastigotes
- Trypanosoma brucei hexokinase 1
- human african trypanosomiasis
- Leishmania major promastigotes
- Inhibitor
- inhibitor
- inhibit