SKLB188
SKLB188 is an orally active and potent epidermal growth factor receptor (EGFR) inhibitor (IC50=5 nM). SKLB188 suppresses MEK/Erk and Akt/mTOR signaling pathways to inhibit head and neck squamous cell carcinoma (HNSCC) proliferation and induce caspase-dependent apoptosis. SKLB188 is promising for research of EGFR-overexpressing solid tumors.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1350545-09-3
- 分子式: C27H31N9O2
- 分子量:513.59
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
EGFR アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCC827 | IC50 |
<0.00001 μM
Compound: 18a
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Cytotoxicity against human HCC827 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human HCC827 cells incubated for 72 hrs by MTT assay
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[PMID: 23116168] |
| HepG2 | IC50 |
>5 μM
Compound: 18a
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Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay
|
[PMID: 23116168] |
| NCI-H1975 | IC50 |
0.98 μM
Compound: 18a
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Cytotoxicity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
|
[PMID: 23116168] |
化学情報
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CAS 番号 1350545-09-3
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分子量 513.59
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分子式 C27H31N9O2
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SMILES
O=[N+](C1=CC(NC2=NC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=C4)N=C3N2C6CCCC6)=CC=C1)[O-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SKLB188 関連分類
HY-120412 関連分類
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