SLC3037
Based on 1 publication(s) in Google Scholar
SLC3037 is a NLRP3 inhibitor which blocks NLRP3 from binding to NEK7 or oligomerization, inhibiting inflammasome caused by MSU and other inflammasome activators. SLC3037 can be used for research of gout, cardiovascular diseases, metabolic syndrome or neurodegenerative diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.85%
- 分子式: C29H35N7OS
- 分子量:529.70
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 SLC3037
More
生物活性
製品説明
IC50 & Target
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NLRP3 |
NEK7 |
体外実験
SLC3037 (1-10 μM, 5 h) inhibits the IL-1β induced by LPS and MSU dose-dependently in BMDMs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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性状 Solid
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分子量 529.70
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分子式 C29H35N7OS
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Color Light yellow to yellow
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SMILES
CN(CCNC(C1=CC(C2=CSC3=C2N=C(N=C3)NC4=CC=C(C=C4)N5CCN(CC5)CC)=CC=C1)=O)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Cell
Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation. [Abstract]2024 Sep 5;84(17):3336-3353.e7. PMID: 39173637
溶剤 & 溶解度
体外:
DMSO : 200 mg/mL (377.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8879 mL | 9.4393 mL | 18.8786 mL | 47.1965 mL |
| 5 mM | 0.3776 mL | 1.8879 mL | 3.7757 mL | 9.4393 mL | |
| 10 mM | 0.1888 mL | 0.9439 mL | 1.8879 mL | 4.7197 mL | |
| 15 mM | 0.1259 mL | 0.6293 mL | 1.2586 mL | 3.1464 mL | |
| 20 mM | 0.0944 mL | 0.4720 mL | 0.9439 mL | 2.3598 mL | |
| 25 mM | 0.0755 mL | 0.3776 mL | 0.7551 mL | 1.8879 mL | |
| 30 mM | 0.0629 mL | 0.3146 mL | 0.6293 mL | 1.5732 mL | |
| 40 mM | 0.0472 mL | 0.2360 mL | 0.4720 mL | 1.1799 mL | |
| 50 mM | 0.0378 mL | 0.1888 mL | 0.3776 mL | 0.9439 mL | |
| 60 mM | 0.0315 mL | 0.1573 mL | 0.3146 mL | 0.7866 mL | |
| 80 mM | 0.0236 mL | 0.1180 mL | 0.2360 mL | 0.5900 mL | |
| 100 mM | 0.0189 mL | 0.0944 mL | 0.1888 mL | 0.4720 mL |
SLC3037 関連分類
HY-163358 関連分類
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