SM-360320
Based on 1 Customer Validation
SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.41%
- CAS 番号: 226907-52-4
- 分子式: C15H17N5O3
- 分子量:315.33
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
1.17 μM
Compound: SM360320
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Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay
Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay
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[PMID: 32001135] |
| HEK293 | EC50 |
399.4 nM
Compound: 3
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Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay
Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay
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[PMID: 20232824] |
| Huh-7 | EC50 |
30 nM
Compound: BHMA
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Antiviral activity against HCV infected in human Huh7 cells with persistent PFK1389-Luc-Ubi-Neo-NS3-3'/ET replicon after 48 hrs by luminescence based assay
Antiviral activity against HCV infected in human Huh7 cells with persistent PFK1389-Luc-Ubi-Neo-NS3-3'/ET replicon after 48 hrs by luminescence based assay
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[PMID: 20028817] |
| PBMC | EC50 |
0.14 μM
Compound: 4, SM360320
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Induction of IFNalpha production in human PBMC
Induction of IFNalpha production in human PBMC
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[PMID: 16784848] |
化学情報
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CAS 番号 226907-52-4
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性状 Solid
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分子量 315.33
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分子式 C15H17N5O3
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Color White to off-white
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SMILES
COCCOC1=NC(N)=C2C(N(C(N2)=O)CC3=CC=CC=C3)=N1
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別名
CL-087
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (396.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Dharmapuri S, et al. An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. Cancer Gene Ther. 2009;16(5):462-472. [Content Brief]
[2]. Lee J, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103(6):1828-1833. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1713 mL | 15.8564 mL | 31.7128 mL | 79.2820 mL |
| 5 mM | 0.6343 mL | 3.1713 mL | 6.3426 mL | 15.8564 mL | |
| 10 mM | 0.3171 mL | 1.5856 mL | 3.1713 mL | 7.9282 mL | |
| 15 mM | 0.2114 mL | 1.0571 mL | 2.1142 mL | 5.2855 mL | |
| 20 mM | 0.1586 mL | 0.7928 mL | 1.5856 mL | 3.9641 mL | |
| 25 mM | 0.1269 mL | 0.6343 mL | 1.2685 mL | 3.1713 mL | |
| 30 mM | 0.1057 mL | 0.5285 mL | 1.0571 mL | 2.6427 mL | |
| 40 mM | 0.0793 mL | 0.3964 mL | 0.7928 mL | 1.9821 mL | |
| 50 mM | 0.0634 mL | 0.3171 mL | 0.6343 mL | 1.5856 mL | |
| 60 mM | 0.0529 mL | 0.2643 mL | 0.5285 mL | 1.3214 mL | |
| 80 mM | 0.0396 mL | 0.1982 mL | 0.3964 mL | 0.9910 mL | |
| 100 mM | 0.0317 mL | 0.1586 mL | 0.3171 mL | 0.7928 mL |
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