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SMER10

SMER10 is a small-molecule enhancer that can induce autophagy. SMER10 can increase the number of EGFP-LC3 positive autophagosoms in COS-7 and HeLa cells, promoting the conversion of LC3-I to autophagosome-associated LC3-II. SMER10 can efficiently promote the degradation of autophagy substrates, including the mutant huntingtin protein (EGFP-HDQ74) associated with Huntington's disease and the A53T α-synuclein protein associated with Parkinson's disease. SMER10 exerts neuroprotective effect.

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  • CAS 番号: 221238-83-1
  • 分子式: C16H17N3O
  • 分子量:267.33
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • SMER10 Chemical Structure
    SMER10 構造式
CAS 番号: 221238-83-1
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    SMER10 Chemical Structure
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  • SMER10