SMS2-IN-3
SMS2-IN-3 is a potent and selective SMS2inhibitor (IC50=2.2 nM), significantly reduces the hepatic SM (22:0) levels.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2414240-89-2
- 分子式: C33H39F3N4O6
- 分子量:644.68
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Phospholipase アイソフォーム固有の製品をすべて表示
More
生物活性
IC50: 2.2nM (SMS2)[1]
SMS2-IN-3 (37) is an excellent sphingomyelin synthase 2 inhibitor (SMS2). SMS2-IN-3 (37) has inhibition (IC50= 2.2 nM) and good selectivity against SMS1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:FreeStyle293 cells
-
Concentration:100mg/kg
-
Incubation Time:60 min
-
Result:Showed excellent SMS2 inhibition and good selectivity against SMS1 in biological evaluation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:KK-Ay/Ta mice[1]
-
Dosage:100, 200 mg/kg
-
Administration:SMS2-IN-3: s.c. (100, 200 mg/kg); p.o. (100, 200 mg/kg); once or twice per day for 7 days.
-
Result:
cmpd Cmax, (μg/mL) Tmax, (h) C24 h, (μg/mL) AUC0-24(μg•h/mL) MRT(h) 37(p.o.) 6.5 0.83 0.007 18 3.0 37(s.c.) 0.70 8.0 0.23 12 9.4
化学情報
-
CAS 番号 2414240-89-2
-
分子量 644.68
-
分子式 C33H39F3N4O6
-
SMILES
O=C(N1CCC(CCCOC(C2=C(N3C)N=CC=C2)=C(C(N(CC4=CC(OC)=CC(C(F)(F)F)=C4)C)=O)C3=O)CC1)OC5(CC5)C
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SMS2-IN-3 関連分類
HY-150559 関連分類
Powered by Bioz