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製品番号: HY-112447

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STAT3-IN-5

STAT3-IN-5 is a potent STAT3 inhibitor. STAT3-IN-5 inhibits STAT3-Y705 phosphorylation with an EC₅₀ value of 170 nM. STAT3-IN-5 inhibits cytokine induced JAK activation. STAT3-IN-5 induces apoptosis. STAT3-IN-5 can be used in research of cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1041438-68-9
分子式: C₁₉H₇F₇N₂O₃
分子量:444.26

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

STAT3-IN-5 構造式

CAS 番号: 1041438-68-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

p-STAT3

170 nM (EC₅₀)

STAT アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
U-266	EC₅₀	0.17 μM Compound: 8	Inhibition of STAT3 Y705 phosphorylation in human U266 cells by Western blot analysis Inhibition of STAT3 Y705 phosphorylation in human U266 cells by Western blot analysis	[PMID: 18578470]

体外実験

STAT3-IN-5 (compound 8; 0-2 μM; 1 h) inhibits STAT3 phosphorylation in U266 cells^[1].
STAT3-IN-5 (0-2 μM; 1 h) inhibits cytokines induced phosphorylation of JAK1, JAK2, and Tyk2 in U266 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

U266 cells
Concentration:

0-2 μM
Incubation Time:

1 hours
Result:

Inhibited cytokine induced phosphorylation of JAK1, JAK2, and Tyk2 (P-JAK1-Y1022/1023, P-JAK2-Y1007/1008, P-Tyk2-Y1054/1055).

Western Blot Analysis^[1]

Cell Line:

U266 cells
Concentration:

0-2 μM
Incubation Time:

1 hours
Result:

Inhibited STAT3 phosphorylation in a dose-dependent manner.

化学情報

CAS 番号 1041438-68-9
分子量 444.26
分子式 C₁₉H₇F₇N₂O₃
SMILES

N#CC1=C(C(F)=C(N2C=C(C(C3=CC(F)=C(C(F)=C32)F)=O)C(OCC)=O)C(F)=C1F)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Xu J, et, al. Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters. J Med Chem. 2008 Jul 24;51(14):4115-21. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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