STL1267
Based on 2 publication(s) in Google Scholar
STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.83%
- CAS 番号: 1429024-58-7
- 分子式: C17H11ClN4O
- 分子量:322.75
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 STL1267
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生物活性
Ki: 0.16 µM (REV-ERBα)[1]
STL1267 (5 µM; 24 h) decreases the expression of BMAL1 and increases the gene expression of Mtnd1, Mtco1, Vicad, Lcad, Scad, Lkb1, Sirt1, Nampt, Ppargc1a in HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2, C2C12 cells
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Concentration:0-20 µM
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Incubation Time:24 h
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Result:Showed no adverse effects on cell viability up to the maximum dose examined 20 µM.
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Cell Line:HepG2 cells
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Concentration:5 µM
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Incubation Time:24 h
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Result:Decreased the gene expression of BMAL1, increased the gene expression of Mtnd1, Mtco1, Vicad, Lcad, Scad, Lkb1, Sirt1, Nampt, Ppargc1a.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-8 weeks, male C57Bl/6 J mice[1]
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Dosage:50 mg/kg
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Administration:I.p.; once
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Result:Showed a plasma half-life of 1.6 h, effectively suppressed BMAL1 expression in the liver at 12 h post-administration.
化学情報
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CAS 番号 1429024-58-7
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性状 Solid
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分子量 322.75
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分子式 C17H11ClN4O
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Color White to off-white
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SMILES
ClC1=NN=C2C=CC(OC3=C(C4=CC=CC=C4)C=CC=C3)=NN12
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Adv Healthc Mater
Porous Microspheres Loading Small Molecule Targeting REV-ERBs Modulate Inflammatory Cytokines Fluctuations to Promote Periodontal Bone Regeneration. [Abstract]2025 Jun 25:e2500867. PMID: 40557559 -
Drug Des Devel Ther
ED-71 Ameliorates Bone Loss in Type 2 Diabetes Mellitus by Enhancing Osteogenesis Through Upregulation of the Circadian Rhythm Coregulator BMAL1. [Abstract]2024 Aug 29:18:3903-3919. PMID: 39224902
溶剤 & 溶解度
DMSO : 25 mg/mL (77.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0984 mL | 15.4919 mL | 30.9837 mL | 77.4593 mL |
| 5 mM | 0.6197 mL | 3.0984 mL | 6.1967 mL | 15.4919 mL | |
| 10 mM | 0.3098 mL | 1.5492 mL | 3.0984 mL | 7.7459 mL | |
| 15 mM | 0.2066 mL | 1.0328 mL | 2.0656 mL | 5.1640 mL | |
| 20 mM | 0.1549 mL | 0.7746 mL | 1.5492 mL | 3.8730 mL | |
| 25 mM | 0.1239 mL | 0.6197 mL | 1.2393 mL | 3.0984 mL | |
| 30 mM | 0.1033 mL | 0.5164 mL | 1.0328 mL | 2.5820 mL | |
| 40 mM | 0.0775 mL | 0.3873 mL | 0.7746 mL | 1.9365 mL | |
| 50 mM | 0.0620 mL | 0.3098 mL | 0.6197 mL | 1.5492 mL | |
| 60 mM | 0.0516 mL | 0.2582 mL | 0.5164 mL | 1.2910 mL |
STL1267 関連分類
HY-148711 関連分類
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