Synucleozid
Based on 2 publication(s) in Google Scholar
Synucleozid (NSC 377363) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein. Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson’s disease.
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- CAS 番号: 502139-01-7
- 分子式: C22H20N6
- 分子量:368.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Synucleozid
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生物活性
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Cell Line
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Type | Value | Description | References |
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| CMK | IC50 |
1.31 μM
Compound: K313
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Antiproliferative activity against human CMK cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human CMK cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
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[PMID: 34046601] |
| HEL | IC50 |
2.27 μM
Compound: K313
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Antiproliferative activity against human HEL cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human HEL cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
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[PMID: 34046601] |
| K562 | IC50 |
1.08 μM
Compound: K313
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Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
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[PMID: 34046601] |
| MEG-01 | IC50 |
1.03 μM
Compound: K313
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Antiproliferative activity against human MEG-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human MEG-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
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[PMID: 34046601] |
Synucleozid (0.25-1 μM; 24 hours) abrogates cytotoxicity induced by α-synuclein preformed fibrils, which act as seeds and recruit endogenous α-synuclein to aggregate[1]. Synucleozid (0-1 μM; 24 hours) binds to the A bulge near the base of the IRE hairpin, reduced levels of α-synuclein in a dose-dependent manner with an IC50 of 500 nM, and inhibits α-synuclein protein expression in SH-SY5Y neuroblastoma cells[1]. Synucleozid (100 nM-100 μM; 24 hours) binds to 2-AP-labeled and native IRE RNA with similar affinities. It decreases 2-AP emission with an EC50 value of 2.7 ± 0.4 μM, recovery of 2-AP emissions is observed as a function of unlabeled SNCA IRE RNA (RNA-0) concentration, affording a competitive Kd of 1.5 ± 0.3 μM[1]. Synucleozid (0.25-1 μM; 24 hours) decreases α-synuclein and other proteins that have IREs in their mRNA’s UTR including APP, PrP, Ferritin and TfR as a dose-dependent mannner. All panels is completed in SH-SY5Y cells, except for PrP protein which is assessed in Neuro-2A cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y neuroblastoma cells
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Concentration:0.25 μM, 0.5 μM, 1 μM
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Incubation Time:24 hours
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Result:Decreased LDH release as a dose-dependent manner.
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Cell Line:SH-SY5Y neuroblastoma cells
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Concentration:0.25 μM; 0.5 μM; 1 μM;
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Incubation Time:24 hours
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Result:Decreased α-synuclein expression as a concentration-dependent manner.
化学情報
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CAS 番号 502139-01-7
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分子量 368.43
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分子式 C22H20N6
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SMILES
N=C(C1=CC2=C(C=C1)C=C(C3=CC=C(NC4=CC=C(C(N)=N)C=C4)C=C3)N2)N
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別名
NSC 377363
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Metab
Ferroplasticity drives social isolation-induced anxiety via a ventral hippocampal iron-α-synuclein axis. [Abstract]2026 Jan 27:S1550-4131(25)00586-8. PMID: 41605214 -
Brain Behav Immun
Transfer of neuron-derived α-synuclein to astrocytes induces neuroinflammation and blood-brain barrier damage after methamphetamine exposure: Involving the regulation of nuclear receptor-associated protein 1. [Abstract]2022 Nov:106:247-261. PMID: 36089218
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Synucleozid 関連分類
HY-135902 関連分類
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