TAK-137
TAK-137 is an AMPA receptor potentiator with weak agonistic effect. TAK-137 binds to the AMPA receptor ligand binding domain in a glutamate-dependent manner. TAK-137 potentiates AMPA-induced currents and Ca2+ influx. TAK-137 can be used for the research of neurological disease.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1358749-55-9
- 分子式: C19H16N2O3S
- 分子量:352.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
AMPA Receptor |
体外実験
TAK-137 (30 μM; 60 min) potentiates AMPA-induced Ca2+ influx in rat primary hippocampal neurons with an EC50 of 0.42 μM and exhibits a 7.6% agonistic effect at 30 μM in the absence of AMPA[1].
TAK-137 (30 μM) potentiates AMPA-induced currents in rat primary hippocampal neurons with an EC50 of 1.4 μM and exhibits a 6.4% agonistic effect at 30 μM in the absence of AMPA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1358749-55-9
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分子量 352.41
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分子式 C19H16N2O3S
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SMILES
O=S1(=O)N=C2C(=CC=CN2CC1)C=3C=CC(OC=4C=CC=CC4)=CC3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TAK-137 関連分類
HY-204388 関連分類
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