TCJL37
Based on 1 Customer Validation
TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.89%
- CAS 番号: 1258294-34-6
- 分子式: C17H11ClF2N4O2
- 分子量:376.74
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[1]|
Tyk2 1.6 nM (Ki) |
体外実験
In cell-based assays, TCJL37 (Compound 37) shows IL-12 pSTAT4 EC50 of 224 nM. TCJL37 shows EC50s of 168 nM and 737 nM In human peripheral blood mononuclear cells (PBMC) and human whole blood assay, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1258294-34-6
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性状 Solid
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分子量 376.74
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分子式 C17H11ClF2N4O2
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Color Light yellow to light brown
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SMILES
O=C(NC1=CC(NC([C@@H]2[C@H](F)C2)=O)=NC=C1)C3=C(F)C=C(C#N)C=C3Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 175 mg/mL (464.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6544 mL | 13.2718 mL | 26.5435 mL | 66.3588 mL |
| 5 mM | 0.5309 mL | 2.6544 mL | 5.3087 mL | 13.2718 mL | |
| 10 mM | 0.2654 mL | 1.3272 mL | 2.6544 mL | 6.6359 mL | |
| 15 mM | 0.1770 mL | 0.8848 mL | 1.7696 mL | 4.4239 mL | |
| 20 mM | 0.1327 mL | 0.6636 mL | 1.3272 mL | 3.3179 mL | |
| 25 mM | 0.1062 mL | 0.5309 mL | 1.0617 mL | 2.6544 mL | |
| 30 mM | 0.0885 mL | 0.4424 mL | 0.8848 mL | 2.2120 mL | |
| 40 mM | 0.0664 mL | 0.3318 mL | 0.6636 mL | 1.6590 mL | |
| 50 mM | 0.0531 mL | 0.2654 mL | 0.5309 mL | 1.3272 mL | |
| 60 mM | 0.0442 mL | 0.2212 mL | 0.4424 mL | 1.1060 mL | |
| 80 mM | 0.0332 mL | 0.1659 mL | 0.3318 mL | 0.8295 mL | |
| 100 mM | 0.0265 mL | 0.1327 mL | 0.2654 mL | 0.6636 mL |
TCJL37 関連分類
HY-16640 関連分類
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