TD-165
Based on 1 publication(s) in Google Scholar
TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group.
(Pink: Cereblon ligand (HY-10984); Blue: VHL ligand (HY-120217); Black: linker (HY-W142804)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.08%
- CAS 番号: 2305936-56-3
- 分子式: C46H59N7O8S
- 分子量:870.07
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 TD-165
MorePROTACs アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
Cereblon 20.4 nM (DC50) |
体外実験
TD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4 nM and 99.6%, respectively[1]. TD-165 (0.1-10 μM; 24 hours) leads to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2305936-56-3
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性状 Solid
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分子量 870.07
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分子式 C46H59N7O8S
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Color White to yellow
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SMILES
O=C([C@H]1N(C([C@@H](NC(CCCCCCCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Osteoarthritis Cartilage
The cereblon-AMPK (AMP-activated protein kinase) axis in chondrocytes regulates the pathogenesis of osteoarthritis. [Abstract]2024 Dec;32(12):1579-1590. PMID: 39218203
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (57.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1493 mL | 5.7467 mL | 11.4933 mL | 28.7333 mL |
| 5 mM | 0.2299 mL | 1.1493 mL | 2.2987 mL | 5.7467 mL | |
| 10 mM | 0.1149 mL | 0.5747 mL | 1.1493 mL | 2.8733 mL | |
| 15 mM | 0.0766 mL | 0.3831 mL | 0.7662 mL | 1.9156 mL | |
| 20 mM | 0.0575 mL | 0.2873 mL | 0.5747 mL | 1.4367 mL | |
| 25 mM | 0.0460 mL | 0.2299 mL | 0.4597 mL | 1.1493 mL | |
| 30 mM | 0.0383 mL | 0.1916 mL | 0.3831 mL | 0.9578 mL | |
| 40 mM | 0.0287 mL | 0.1437 mL | 0.2873 mL | 0.7183 mL | |
| 50 mM | 0.0230 mL | 0.1149 mL | 0.2299 mL | 0.5747 mL |
TD-165 関連分類
HY-130714 関連分類
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