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製品番号: HY-101040A

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Telacebec ditosylate

(別名: Q203 ditosylate; IAP6 ditosylate)

7 Cited Publications

カスタマーレビュー

Based on 7 publication(s) in Google Scholar

Telacebec ditosylate is a midazopyridine amide compound. Telacebec ditosylate is active against Mycobacterium tuberculosis H37Rv with an MIC₅₀ of 2.7 nM in culture broth medium.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1566517-83-6
分子式: C₄₃H₄₄ClF₃N₄O₈S₂
分子量:901.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Telacebec ditosylate 構造式

CAS 番号: 1566517-83-6

容量

価格（税別）

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Telacebec ditosylate is a midazopyridine amide compound. Telacebec ditosylate is active against Mycobacterium tuberculosis H37Rv with an MIC₅₀ of 2.7 nM in culture broth medium.

Antibiotic アイソフォーム固有の製品をすべて表示 :

化学情報

CAS 番号 1566517-83-6
分子量 901.41
分子式 C₄₃H₄₄ClF₃N₄O₈S₂
SMILES

O=C(NCC1=CC=C(C=C1)N2CCC(CC2)C3=CC=C(C=C3)OC(F)(F)F)C4=C(N=C5C=CC(Cl)=CN54)CC.O=S(C6=CC=C(C=C6)C)(O)=O.O=S(C7=CC=C(C=C7)C)(O)=O
別名

Q203 ditosylate; IAP6 ditosylate
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (7)

All Bio/Physico-chemical AssayMicrobiological Assay

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Eur J Med Chem

Design, synthesis and biological evaluation of (Quinazoline 4-yloxy)acetamide and (4-oxoquinazoline-3(4H)-yl)acetamide derivatives as inhibitors of Mycobacterium tuberculosis bd oxidase. [Abstract]

2022 Nov 15:242:114639. PMID: 35973312
Int J Mol Sci

Response of Mycobacterium smegmatis to the Cytochrome bcc Inhibitor Q203. [Abstract]

2022 Sep 7;23(18):10331. PMID: 36142240

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

M. smegmatis wild-type (WT) and M. smegmatis mutant strain with knocked-out cytochrome bd (bd-KO) in the presence and absence of indicated Q203 (Telacebec, 0-10 μM, 0-80 h) concentrations.

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

The outgrowth of M. smegmatis bd-KO in presence of Q203 is not due to selection of mutant harboring compensatory mutations. After eventual growth resumption in presence of Q203 (Telacebec) at ~40 h (green curve), the bacteria were re-treated with Q203 (Telacebec) by diluting into fresh 7H9 complete medium containing the drug (blue curve) or re-grown in drug-free 7H9 complete medium for 16 h, and subsequently again diluted into fresh 7H9 complete medium containing the drug.

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

Quantification of surviving M. smegmatis bd-KO after exposure to Q203 (Telacebec, 10 μM, 0-48 h) in 7H9 complete medium for the indicated time. Colony forming units (CFU/mL) were subsequently counted on agar plates after three days of incubation at 37 °C. Data are Mean ± SD from two independent experiments (biological replicates), each comprising three technical replicates.

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

Representative dilution series of M. smegmatis bd-KO after exposure to Q203 (Telacebec) in 7H9 complete medium for the indicated time. Each spot represents a 5 µL aliquot.
ACS Infect Dis

Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis. [Abstract]

2021 Jan 8;7(1):141-152. PMID: 33319550
Antimicrob Agents Chemother

Nitric Oxide-Dependent Electron Transport Chain Inhibition by the Cytochrome bc1 Inhibitor and Pretomanid Combination Kills Mycobacterium tuberculosis. [Abstract]

2021 Aug 17;65(9):e0095621. PMID: 34152815
Microbiol Spectr

GaMF1.39's antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876. [Abstract]

2023 Dec 12;11(6):e0228223. PMID: 37982630
bioRxiv

2024 June 11.
Elife

Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. [Abstract]

2021 Nov 25;10:e69418. PMID: 34819223

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Elife. 2021 Nov 25;10:e69418. [Abstract]

Rate of O₂ reduction by the hybrid supercomplex before and after addition of Q203(Telacebec).

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Pethe K, et al. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat Med. 2013 Sep;19(9):1157-60. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Telacebec ditosylate

7 Cited Publications

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生物活性
- 製品説明
化学情報
Publications (7)
純度とドキュメンテーション
参考文献

1/16
1/16

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

Customer Validation
M. smegmatis wild-type (WT) and M. smegmatis mutant strain with knocked-out cytochrome bd (bd-KO) in the presence and absence of indicated Q203 (Telacebec, 0-10 μM, 0-80 h) concentrations.
1/16

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

Customer Validation
The outgrowth of M. smegmatis bd-KO in presence of Q203 is not due to selection of mutant harboring compensatory mutations. After eventual growth resumption in presence of Q203 (Telacebec) at ~40 h (green curve), the bacteria were re-treated with Q203 (Telacebec) by diluting into fresh 7H9 complete medium containing the drug (blue curve) or re-grown in drug-free 7H9 complete medium for 16 h, and subsequently again diluted into fresh 7H9 complete medium containing the drug.
1/16

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

Customer Validation
Quantification of surviving M. smegmatis bd-KO after exposure to Q203 (Telacebec, 10 μM, 0-48 h) in 7H9 complete medium for the indicated time. Colony forming units (CFU/mL) were subsequently counted on agar plates after three days of incubation at 37 °C. Data are Mean ± SD from two independent experiments (biological replicates), each comprising three technical replicates.
1/16

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

Customer Validation
Representative dilution series of M. smegmatis bd-KO after exposure to Q203 (Telacebec) in 7H9 complete medium for the indicated time. Each spot represents a 5 µL aliquot.
1/16

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Elife. 2021 Nov 25;10:e69418. [Abstract]

Customer Validation
Rate of O₂ reduction by the hybrid supercomplex before and after addition of Q203(Telacebec).

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Telacebec ditosylate

MedChemExpress（MCE）の使用を引用している文献 Telacebec ditosylate

Antibiotic アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (7)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Telacebec ditosylate 関連分類

HY-101040A 関連分類