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製品番号: HY-122903S

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TK216-d₄

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TK216-d₄ is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.52%
CAS 番号: 3034816-36-6
分子式: C₁₉H₁₁D₄Cl₂NO₃
分子量:380.26

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

TK216-d₄ 構造式

CAS 番号: 3034816-36-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- アプリケーション
化学情報
純度とドキュメンテーション
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生物活性

製品説明

TK216-d₄ is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor^[1]. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity^[2].

IC₅₀ & Target

Helicase

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

体外実験

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

アプリケーション

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

化学情報

CAS 番号 3034816-36-6
非標識Cas 1903783-48-1
性状 Solid
分子量 380.26
分子式 C₁₉H₁₁D₄Cl₂NO₃
Color White to off-white
SMILES

O=C1NC2=C(C1(O)CC(C3=C([2H])C([2H])=C(C([2H])=C3[2H])C4CC4)=O)C(Cl)=CC=C2Cl
輸送条件

Room temperature in continental US; may vary elsewhere.