trans-4-Hydroxycyclohexanecarboxylic acid
Based on 1 Customer Validation
trans-4-Hydroxycyclohexanecarboxylic acid is a substrate for cyclohexanecarboxylic acid production. trans-4-Hydroxycyclohexanecarboxylic acid is the by-product of intestinal bacterial metabolism via urinary excretion.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.57%
- CAS 番号: 3685-26-5
- 分子式: C7H12O3
- 分子量:144.17
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
IC50: substrate for cyclohexanecarboxylic acid[1]; by-product of intestinal bacterial metabolism[2]
化学情報
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CAS 番号 3685-26-5
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性状 Solid
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分子量 144.17
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分子式 C7H12O3
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Color White to off-white
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SMILES
OC([C@H]1CC[C@@H](CC1)O)=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
DMSO : 100 mg/mL (693.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (346.81 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (17.34 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (17.34 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
純度とドキュメンテーション
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データシート (270 KB)
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SDS (396 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Montaño A, et al. 4-Hydroxycyclohexanecarboxylic Acid as a Substrate for Cyclohexanecarboxylic Acid Production during the " Zapatera " Spoilage of Spanish-Style Green Table Olives.J Food Prot. 1996 Jun;59(6):657-662. [Content Brief]
[2]. Kronick JB, et al. Apparent gastrointestinal origin of cis-4-hydroxycyclohexanecarboxylic acid.Clin Chim Acta. 1983 Aug 15;132(2):205-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 6.9363 mL | 34.6813 mL | 69.3626 mL | 173.4064 mL |
| 5 mM | 1.3873 mL | 6.9363 mL | 13.8725 mL | 34.6813 mL | |
| 10 mM | 0.6936 mL | 3.4681 mL | 6.9363 mL | 17.3406 mL | |
| 15 mM | 0.4624 mL | 2.3121 mL | 4.6242 mL | 11.5604 mL | |
| 20 mM | 0.3468 mL | 1.7341 mL | 3.4681 mL | 8.6703 mL | |
| 25 mM | 0.2775 mL | 1.3873 mL | 2.7745 mL | 6.9363 mL | |
| 30 mM | 0.2312 mL | 1.1560 mL | 2.3121 mL | 5.7802 mL | |
| 40 mM | 0.1734 mL | 0.8670 mL | 1.7341 mL | 4.3352 mL | |
| 50 mM | 0.1387 mL | 0.6936 mL | 1.3873 mL | 3.4681 mL | |
| 60 mM | 0.1156 mL | 0.5780 mL | 1.1560 mL | 2.8901 mL | |
| 80 mM | 0.0867 mL | 0.4335 mL | 0.8670 mL | 2.1676 mL | |
| 100 mM | 0.0694 mL | 0.3468 mL | 0.6936 mL | 1.7341 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
trans-4-Hydroxycyclohexanecarboxylic acid 関連分類
HY-76199 関連分類
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