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United States

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製品番号: HY-N21700

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Uralodin A

Uralodin A is a polycyclic polyprenylated acylphloroglucinol (PPAP). Uralodin A exerts cytotoxic activity through its inhibitory effects on tumor cells. Uralodin A can be used for cancer-related research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1189125-05-0
分子式: C₃₈H₅₀O₅
分子量:586.80

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Uralodin A 構造式

CAS 番号: 1189125-05-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC50	59.7 μM	Cytotoxic activity against human HepG2 tumor cells measured by MTT assay after continuous exposure for 48 h. Cytotoxic activity against human HepG2 tumor cells measured by MTT assay after continuous exposure for 48 h.	20087990
SGC-7901	IC50	27.1 μM	Cytotoxic activity against human SGC7901 tumor cells measured by MTT assay after continuous exposure for 48 h. Cytotoxic activity against human SGC7901 tumor cells measured by MTT assay after continuous exposure for 48 h.	20087990
HL-60	IC50	16.0 μM	Cytotoxic activity against human HL-60 tumor cells measured by MTT assay after continuous exposure for 48 h. Cytotoxic activity against human HL-60 tumor cells measured by MTT assay after continuous exposure for 48 h.	20087990
K562	IC50	23.7 μM	Cytotoxic activity against human K562 tumor cells measured by MTT assay after continuous exposure for 48 h. Cytotoxic activity against human K562 tumor cells measured by MTT assay after continuous exposure for 48 h.	20087990

体外実験

Anti-cancer

Uralodin A (compound 5) (0.064-40 μM; 48 h) exhibits moderate cytotoxic activity against HepG2, SGC7901, HL-60, and K562 cell lines, with IC₅₀ values all below 60 μM, and shows the strongest effect on HL-60 cells (16.0 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HepG2, SGC7901, HL-60, K562
Concentration:

0.064, 0.32, 1.6, 8, 40 μM
Incubation Time:

48 h
Result:

Exhibited cytotoxic activity against all four tested tumor cell lines.
Had an IC50 value of 59.7 μM against HepG2 cells.
Had an IC50 value of 27.1 μM against SGC7901 cells.
Had an IC50 value of 16.0 μM against HL-60 cells.
Had an IC50 value of 23.7 μM against K562 cells.
Showed the highest potency against the HL-60 cell line.
Showed the lowest potency against the HepG2 cell line.

Related Protocols :

化学情報

CAS 番号 1189125-05-0
分子量 586.80
分子式 C₃₈H₅₀O₅
SMILES

O=C(C1=CC=CC=C1)[C@@]23[C@@](C)([C@H](C[C@]4(C(O[C@@H](C4)C(C)(O)C)=C(C3=O)C/C=C(C)\C)C2=O)C/C=C(C)\C)CC/C=C(C)/C
Structure Classification
- Terpenoids
- Other Terpenoids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Chen XQ, et al. Polycyclic polyprenylated acylphloroglucinols and chromone O-glucosides from Hypericum henryi subsp. uraloides. Chemistry & biodiversity. 2010 Jan;7(1):196-204.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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