UU-T02
Based on 1 publication(s) in Google Scholar
UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.94%
- CAS 番号: 1500080-17-0
- 分子式: C33H33ClN4O9
- 分子量:665.09
-
保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 UU-T02
More
生物活性
Ki: 1.36 μM (β-catenin/Tcf PPI)[1].
IC50: 6.3 μM (β-catenin/Tcf4), 680 μM (β-catenin/E-cadherin) , 210 μM (β-catenin/APC-R3)[2].
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| SW480 | IC50 |
231.9 μM
Compound: 42; UU-T02
|
Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth by MTS assay
Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth by MTS assay
|
[PMID: 36183504] |
UU-T02 displays Ki values of 1.4 μM and 1.3 μM for β-catenin/Tcf PPI in FP assay and in AlphaScreen assay, respectively[2].
UU-T02 inhibits β-catenin/Tcf4, β-catenin/E-cadherin, β-catenin/APC-R3, with the IC50 of 6.3, 680, 210 μM，respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 1500080-17-0
-
性状 Solid
-
分子量 665.09
-
分子式 C33H33ClN4O9
-
Color Off-white to light yellow
-
SMILES
OC(CC[C@@H](C(OC)=O)NC([C@H](CC(O)=O)NC([C@H](CC1=CC2=C(C=CC=C2)C=C1)NC(CC3=CC4=CC(Cl)=CC=C4N3)=O)=O)=O)=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Int J Mol Sci
2023 Apr 4;24(7):6733. PMID: 37047705
溶剤 & 溶解度
DMSO : 125 mg/mL (187.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (275 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Huang Z, et al. Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions. ACS Chem Biol. 2014;9(1):193-201. [Content Brief]
[2]. Catrow JL, et al. Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J Med Chem. 2015;58(11):4678-4692. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5036 mL | 7.5178 mL | 15.0356 mL | 37.5889 mL |
| 5 mM | 0.3007 mL | 1.5036 mL | 3.0071 mL | 7.5178 mL | |
| 10 mM | 0.1504 mL | 0.7518 mL | 1.5036 mL | 3.7589 mL | |
| 15 mM | 0.1002 mL | 0.5012 mL | 1.0024 mL | 2.5059 mL | |
| 20 mM | 0.0752 mL | 0.3759 mL | 0.7518 mL | 1.8794 mL | |
| 25 mM | 0.0601 mL | 0.3007 mL | 0.6014 mL | 1.5036 mL | |
| 30 mM | 0.0501 mL | 0.2506 mL | 0.5012 mL | 1.2530 mL | |
| 40 mM | 0.0376 mL | 0.1879 mL | 0.3759 mL | 0.9397 mL | |
| 50 mM | 0.0301 mL | 0.1504 mL | 0.3007 mL | 0.7518 mL | |
| 60 mM | 0.0251 mL | 0.1253 mL | 0.2506 mL | 0.6265 mL | |
| 80 mM | 0.0188 mL | 0.0940 mL | 0.1879 mL | 0.4699 mL | |
| 100 mM | 0.0150 mL | 0.0752 mL | 0.1504 mL | 0.3759 mL |
UU-T02 関連分類
HY-117233 関連分類
Powered by Bioz