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製品番号: HY-129808

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VPC12249

VPC12249 is a competitive dual LPA1/LPA3 antagonist with K_i values of 137nM and 428 nM, respectively. VPC12249 inhibits calcium mobilization in HEK293T cells with a K_i value of ~130 nM. VPC12249 is promising for research of ovarian cancer and hypertensive diseases.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 403520-23-0
分子式: C₃₄H₅₂NO₆P
分子量:601.75

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

VPC12249 構造式

CAS 番号: 403520-23-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

LPL Receptor アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	>10000 nM Compound: 14a	In vitro antagonism of LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 3 in HEK293T cell lines In vitro antagonism of LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 3 in HEK293T cell lines	[PMID: 15125924]
HEK-293T	IC₅₀	>10000 nM Compound: 14a	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	[PMID: 15125924]
HEK-293T	IC₅₀	5210 nM Compound: 20	Antagonist activity at mouse LPA1 receptor transfected in HEK293T cells Antagonist activity at mouse LPA1 receptor transfected in HEK293T cells	10.1039/C4MD00333K
HEK-293T	IC₅₀	6450 nM Compound: 20	Antagonist activity at human LPA3 receptor transfected in HEK293T cells Antagonist activity at human LPA3 receptor transfected in HEK293T cells	10.1039/C4MD00333K

化学情報

CAS 番号 403520-23-0
分子量 601.75
分子式 C₃₄H₅₂NO₆P
SMILES

CCCCCCCC/C=C\CCCCCCCC(N[C@@H](CC1=CC=C(OCC2=CC=CC=C2)C=C1)COP(O)(O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (262 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Heise CE, et al. Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist. Mol Pharmacol. 2001 Dec;60(6):1173-80. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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