VT102
VT102 is a TEAD1 inhibitor with a human IC50 of 391 nM. VT102 inhibits auto-palmitoylation, attenuates YAP/TEAD1 interaction, reduces expression of TEAD target genes, and inhibits YAP-mediated luciferase reporter activity. VT102 exerts weak cell growth inhibitory activity in cancer cells. VT102 can be used for the research of cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1119382-90-9
- 分子式: C21H20BrN5OS
- 分子量:470.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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TEAD1 391 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H2052 | IC50 |
2030 nM
Compound: 40; VT102
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Antiproliferative activity against human NCI-H2052 cells
Antiproliferative activity against human NCI-H2052 cells
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[PMID: 39047607] |
VT102 inhibits YAP-mediated luciferase activity in a reporter assay with an IC50 of 391 nM, blocks TEAD1 auto-palmitoylation, reduces TEAD target gene expression, disrupts YAP/TEAD1 interactions in NCI-H2373 cell lysate, and shows weak growth inhibition in NCI-H2052 cells with an IC50 of 2030 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1119382-90-9
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分子量 470.39
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分子式 C21H20BrN5OS
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SMILES
O=C(C1=CC(N=C(N(C)C)N2C3=CC=C(C=C3)Br)=C2S1)NC(C)C4=NC=CC=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
VT102 関連分類
HY-182673 関連分類
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