WRC-0571
WRC-0571 is an orally effective, potent, and selective non-xanthine adenosine A1 receptor antagonist with a Ki value of 1.7 nM for the human A1 receptor. WRC-0571 competitively binds to and blocks adenosine A1 receptor, thereby inhibiting downstream signaling and physiological responses. WRC-0571 can be used for research on bradycardia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 175097-37-7
- 分子式: C17H26N6O
- 分子量:330.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Adenosine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[3]|
human A1 1.7 nM (Ki) |
rat A1 1.1 nM (Ki) |
hA3 7940 nM (Ki) |
体外実験
WRC-0571 (2.5 h) binds to recombinant rat A3 adenosine receptors with an IC50 of 23.2 μM in HEK-293 cell membranes[1].
WRC-0571 (1 μM) does not block A3 AR-mediated Akt phosphorylation in RBL-2H3 cells[2].
WRC-0571 is a potent non-xanthine A1 antagonist with high affinity for the human A1 receptor (Ki = 1.7 nM) and 200-fold selectivity over the A2A receptor[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 175097-37-7
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分子量 330.43
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分子式 C17H26N6O
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SMILES
CC(C)N(C)C1=NC(C(N[C@H]2[C@@H]3C[C@@H]([C@H](O)C3)C2)=NC=N4)=C4N1C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
WRC-0571 関連分類
HY-105345 関連分類
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