XY-06-005
XY-06-005 is a modified selective inhibitor of BET bromodomain that binds to BRD4 BD1 L94V, BRD4 BD2 L387V and BRD2 BD2 L383V. XY-06-005 serves as a Ligand for Target Protein for PROTAC for studies related to PROTAC synthesis, such as acting as the target protein ligand structure of XY-06-007 (HY-145226).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1642783-78-5
- 分子式: C22H21ClN4O3
- 分子量:424.88
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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BRD4 BD1 |
BRD4 BD2 |
BRD4 BD1L94V |
XY-06-005 (compound 3) potently binds to mutant bromodomains (BRD4 BD1 L94V, BRD4 BD2 L387V, BRD2 BD2 L383V) with IC50 values ranging from 62 nM to 231 nM. In contrast, it shows significantly weaker binding affinity to wild-type BRD4 BD1 (39 nM) and BRD4 BD2 (863 nM), indicating its selectivity for mutant bromodomains over wild-type counterparts[1].
XY-06-005 can serve as the target protein ligand structure of XY-06-007 (HY-145226). XY-06-007 is a potent and selective B&H-PROTAC BRD4 BD1 L94V degrader with a DC50 of 10 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1642783-78-5
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分子量 424.88
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分子式 C22H21ClN4O3
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SMILES
ClC1=CC=C(C2=N[C@H](C3=NN=C(N3C4=C2C=C(C=C4)OC)C)[C@H](C(OC)=O)C)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
XY-06-005 関連分類
HY-184949 関連分類
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