XYDC2050

XYDC2050 (Compound 29) is a selective vasopressin V2 receptor (V2R) antagonist with an IC₅₀ of 27 nM and a K_i of 2.8 nM. XYDC2050 shows a K_i of 420.7 nM (SI = 162 fold) for V1R. XYDC2050 can inhibit Vasopressin (HY-B1811)-induced intracellular cyclic adenosine monophosphate (cAMP) accumulation with an IC₅₀ of 12 nM. XYDC2050 can inhibit the growth of renal cysts, reduce the ratio of kidney weight to body weight and decrease the area of cysts and the cystic index. XYDC2050 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD).

• Data Sheet (271 KB)