YMU1
Based on 1 Customer Validation
YMU1 is a selective inhibitor of human thymidylate kinase (hTMPK) with an IC50 of 610 nM. YMU1 inhibits tumor proliferation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.19%
- CAS 番号: 902589-96-2
- 分子式: C17H22N4O4S
- 分子量:378.45
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
Anti-Lung Cancer Compound Library
HY-L075
-
Anti-Pancreatic Cancer Compound Library
HY-L077
-
Anti-Obesity Compound Library
HY-L087
-
Transcription Factor-Targeted Library
HY-L090
-
Heterocyclic Compound Library
HY-L138
-
Highly Selective Activators Library
HY-L159
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Cell Proliferation Compound Library
HY-L201
-
High-Throughput Bioactive Compound Library
HY-L205
-
Lactylation Compound Library
HY-L249
-
Immunology/Inflammation Compound Library
HY-L007
-
JAK/STAT Compound Library
HY-L008
-
Stem Cell Signaling Compound Library
HY-L017
-
Anti-Cancer Compound Library
HY-L025
-
Small Molecule Immuno-Oncology Compound Library
HY-L031
-
Anti-Aging Compound Library
HY-L034
生物活性
|
STAT3 |
YMU1 (0.1-10 μM, 10 min) has no inhibitory effect on TK1[1].
YMU1 is not toxic to the genome and, similar to TMPK silencing, impaires DSB repair[1].
YMU1 (1-10 μM, 14 days) has little effect on cell growth in H184B5F5M10, MCF10A, MCF-7, and HCT-116 cells[1].
YMU1 does not inhibit dUTPase in vitro[1].
YMU1 sensitizes malignant tumor cells to doxorubicin in vitro[1].
YMU1 (3-10 μM, 72 h) inhibits A549 cell proliferation, migration, and invasion[2].
YMU1 (3-10 μM, 72 h) controls the activation of STAT3 signaling pathway in LUAD cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:H184B5F5M10, MCF10A, MCF-7, HCT-116
-
Concentration:1, 10 μM
-
Incubation Time:14 days; twice a week
-
Result:Had little effect on cell growth.
-
Cell Line:A549
-
Concentration:3, 10 μM
-
Incubation Time:72 h
-
Result:Decreased cell viability.
-
Cell Line:A549
-
Concentration:3, 10 μM
-
Incubation Time:72 h
-
Result:Inhibited cell migration.
-
Cell Line:A549
-
Concentration:3, 10 μM
-
Incubation Time:72 h
-
Result:Inhibited cell invasion.
-
Cell Line:A549; LUAD
-
Concentration:3, 10 μM
-
Incubation Time:72 h
-
Result:Increased E-Cadherin approximately 3-fold, reduced N-Cadherin, fibronectin, and vimentin by more than 50%, and significantly reduced pSTAT3 levels, while total STAT3 levels had no significant change.
YMU1 (3-10 mg/kg, intraperitoneal injection, once every two days, for 30 days) inhibits the growth of A549 xenograft tumors in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:HCT-116 p53-/- cell transplantation model in nude mice[1]
-
Dosage:5 mg/kg; 3 times a week; 25 days
-
Administration:Intraperitoneal injection (i.p.)
-
Result:Showed that tumors grew significantly slower in mice treated with doxorubicin.
-
Animal Model:A549 nude mouse transplantation model[2]
-
Dosage:3,10 mg/kg; once every two days; 30 days
-
Administration:Intraperitoneal injection (i.p.)
-
Result:Reduced tumor volume and weight in a dose-dependent manner.
化学情報
-
CAS 番号 902589-96-2
-
性状 Solid
-
分子量 378.45
-
分子式 C17H22N4O4S
-
Color Off-white to light yellow
-
SMILES
O=C(N1CCN(C(CN2SC3=NC(C)=CC(C)=C3C2=O)=O)CC1)OCC
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 5.56 mg/mL (14.69 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (276 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6424 mL | 13.2118 mL | 26.4236 mL | 66.0589 mL |
| 5 mM | 0.5285 mL | 2.6424 mL | 5.2847 mL | 13.2118 mL | |
| 10 mM | 0.2642 mL | 1.3212 mL | 2.6424 mL | 6.6059 mL |
YMU1 関連分類
HY-129125 関連分類
Powered by Bioz