Zolantidine
Zolantidine (SKF 95282) is a potent, selective and cross the blood-brain barrier histamine H2 antagonist. Zolantidine induces antinociception.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 104076-38-2
- 分子式: C22H27N3OS
- 分子量:381.53
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Histamine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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H2 Receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
76 μM
Compound: Zolantidine
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Cytotoxicity activity against human HepG2 cells after 24 hrs
Cytotoxicity activity against human HepG2 cells after 24 hrs
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[PMID: 20547797] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:200-250 g, male Wistar rats (cholestatic rats)[2]
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Dosage:5, 10, 20, 40 mg/kg
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Administration:S.c.
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Result:Significantly increased tail-flick latencies and induced antinociception.
化学情報
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CAS 番号 104076-38-2
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分子量 381.53
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分子式 C22H27N3OS
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SMILES
C1(NCCCOC2=CC=CC(CN3CCCCC3)=C2)=NC4=CC=CC=C4S1
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別名
SK&F 95282
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Calcutt CR, et al. Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist. Br J Pharmacol. 1988 Jan;93(1):69-78. [Content Brief]
[2]. Hasanein P. Two histamine H2 receptor antagonists, zolantidine and cimetidine, modulate nociception in cholestatic rats. J Psychopharmacol. 2011 Feb;25(2):281-8. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Zolantidine 関連分類
HY-101373 関連分類
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