2. Immunology/Inflammation
  3. Interleukin Related
  4. Kaempferol 3-O-β-D-glucuronide

Kaempferol 3-O-β-D-glucuronide  (Synonyms: Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide)

Cat. No.: HY-N7176 Purity: 99.41%
COA Handling Instructions

Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10.

For research use only. We do not sell to patients.

Kaempferol 3-O-β-D-glucuronide Chemical Structure

Kaempferol 3-O-β-D-glucuronide Chemical Structure

CAS No. : 22688-78-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 381 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 381 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 150 In-stock
Estimated Time of Arrival: December 31
5 mg USD 375 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Kaempferol 3-O-β-D-glucuronide

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  • References

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Description

Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10[1][2].

IC50 & Target[1][2]

IL-1β

 

IL-10

 

Molecular Weight

462.36

Appearance

Solid

Formula

C21H18O12
CAS No.
SMILES

O[[email protected]]([[email protected]]([[email protected]@H]([[email protected]@H](C(O)=O)O1)O)O)[[email protected]@H]1OC2=C(C3=CC=C(O)C=C3)OC4=CC(O)=CC(O)=C4C2=O
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (216.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1628 mL 10.8141 mL 21.6282 mL
5 mM 0.4326 mL 2.1628 mL 4.3256 mL
10 mM 0.2163 mL 1.0814 mL 2.1628 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.41%

COA (257 KB) HNMR (194 KB) RP-HPLC (134 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Kaempferol 3-O-β-D-glucuronide22688-78-4Kaempferol-3-glucuronide Kaempferol-3-O-glucuronideInterleukin RelatedILRAW 264.7cellsmicemodelsecretionanti-inflammatorycytokineLPSInhibitorinhibitorinhibit

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