Ketoprofen-13C,d3
Based on 1 Customer Validation
Ketoprofen-13C,d3 is the 13C- and deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1189508-77-7
- Formula: C1513CH11D3O3
- Molecular Weight:258.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>50 μM
Compound: Ketoprofen
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
|
[PMID: 32987314] |
| A549 | IC50 |
>50 μM
Compound: Ketoprofen
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 32987314] |
| A549 | IC50 |
>50 μM
Compound: Ketoprofen
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 32987314] |
| DU-145 | IC50 |
>100 μM
Compound: 5; Ket
|
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
|
[PMID: 36257283] |
| HeLa | IC50 |
>50 μM
Compound: Ketoprofen
|
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
|
[PMID: 32987314] |
| HeLa | IC50 |
>50 μM
Compound: Ketoprofen
|
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 32987314] |
| HeLa | IC50 |
>50 μM
Compound: Ketoprofen
|
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 32987314] |
| HT-29 | IC50 |
>100 μM
Compound: 5; Ket
|
Antiproliferative activity against human HT-29 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells incubated for 48 hrs by MTT assay
|
[PMID: 36257283] |
| MCF7 | IC50 |
>100 μM
Compound: 5; Ket
|
Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
|
[PMID: 36257283] |
| MCF7 | IC50 |
>50 μM
Compound: Ketoprofen
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
|
[PMID: 32987314] |
| MCF7 | IC50 |
>50 μM
Compound: Ketoprofen
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 32987314] |
| MCF7 | IC50 |
>50 μM
Compound: Ketoprofen
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 32987314] |
| SW480 | IC50 |
>50 μM
Compound: Ketoprofen
|
Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
|
[PMID: 32987314] |
| SW480 | IC50 |
>50 μM
Compound: Ketoprofen
|
Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 32987314] |
| SW480 | IC50 |
>50 μM
Compound: Ketoprofen
|
Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 32987314] |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1189508-77-7
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Unlabeled Cas 22071-15-4
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Molecular Weight 258.29
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Formula C1513CH11D3O3
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SMILES
O=C(C1=CC=CC=C1)C2=CC(C([13C]([2H])([2H])[2H])C(O)=O)=CC=C2
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Synonyms
RP-19583-13C,d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]
[2]. Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12(4):533-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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