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Cat. No.: HY-P10579

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123B9

Name: 123B9
Brand: MedChemExpress
SKU: HY-P10579
Price: 80.00 USD
Availability: InStock
Rating: 5 (1 reviews)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

123B9, a tumor-homing agent, is a potent and selective EphA2 agonist with a K_d value of 4.0 μM. 123B9 selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain. 123B9 does not appreciably inhibit the ligand binding domains of the most closely related EphA3 and EphA4 receptors.

For research use only. We do not sell to patients.

Purity : 98.71%
CAS No.: 2225868-19-7
Formula: C₅₈H₈₂ClFN₁₂O₂₀
Molecular Weight:1321.79

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

123B9 Chemical Structure

CAS No.: 2225868-19-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Kd: 4.0 μM (EphA2)^[1]

All Ephrin Receptor Isoforms :

EphB
EphA

In Vivo

In mice, the mean plasma concentration over time following 123B9 IV administration (30 mg/kg) indicated that the compound is detectable in vivo at each time point tested (30 min, 1 hr, 2 hr, 4 hr) with a mean concentration in plasma of 447 ng/mL and 569 ng/mL still detectable at 2 hr and 4 hr, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2225868-19-7
Appearance Solid
Molecular Weight 1321.79
Formula C₅₈H₈₂ClFN₁₂O₂₀
Color White to off-white
Sequence

{2-(3-chloro-4-fluorophenoxy)acetic acid}-Ser-Ala-Tyr-Pro-Asp-Ser-Val-Pro-{Nle}-{Hsr}-Ser-NH2
Sequence Shortening

{2-(3-chloro-4-fluorophenoxy)acetic acid}-SAYPDSVP-{Nle}-{Hsr}-S-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Eur J Med Chem

Targeting both wild-type EGFR and its drug-resistant mutants with erlotinib-aptamer conjugates. [Abstract]

2025 Oct 15:296:117871. PMID: 40554308

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (75.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.7565 mL

3.7827 mL

7.5655 mL

5 mM

0.1513 mL

0.7565 mL

1.5131 mL

10 mM

0.0757 mL

0.3783 mL

0.7565 mL

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bainan Wu, et al. Design and Characterization of Novel EphA2 Agonists for Targeted Delivery of Chemotherapy to Cancer Cells. Chem Biol. 2015 Jul 23;22(7):876-887. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.7565 mL	3.7827 mL	7.5655 mL	18.9137 mL
	5 mM	0.1513 mL	0.7565 mL	1.5131 mL	3.7827 mL
	10 mM	0.0757 mL	0.3783 mL	0.7565 mL	1.8914 mL
	15 mM	0.0504 mL	0.2522 mL	0.5044 mL	1.2609 mL
	20 mM	0.0378 mL	0.1891 mL	0.3783 mL	0.9457 mL
	25 mM	0.0303 mL	0.1513 mL	0.3026 mL	0.7565 mL
	30 mM	0.0252 mL	0.1261 mL	0.2522 mL	0.6305 mL
	40 mM	0.0189 mL	0.0946 mL	0.1891 mL	0.4728 mL
	50 mM	0.0151 mL	0.0757 mL	0.1513 mL	0.3783 mL
	60 mM	0.0126 mL	0.0630 mL	0.1261 mL	0.3152 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

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CAS No.:
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123B9

Publications Citing Use of MedChemExpress (MCE) 123B9

All Ephrin Receptor Isoforms