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Cat. No.: HY-123915

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Antimalarial agent 20

Antimalarial agent 20 (Compound 49c) is an antimalarial agent with an IC₅₀ of 0.6 nM against P. falciparum NF54 parasite strain in the NF54 albumax assay.

For research use only. We do not sell to patients.

CAS No.: 1422207-75-7
Formula: C₃₁H₃₈N₄O₃
Molecular Weight:514.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Antimalarial agent 20 Chemical Structure

CAS No.: 1422207-75-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Antimalarial agent 20 (Compound 49c) is an antimalarial agent with an IC₅₀ of 0.6 nM against P. falciparum NF54 parasite strain in the NF54 albumax assay^[1].

All Parasite Isoforms :

In Vitro

Antimalarial agent 20 (Compound 49c) shows good in vitro metabolic stability (below 100 μL/(min mg))^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 1422207-75-7
Molecular Weight 514.66
Formula C₃₁H₃₈N₄O₃
SMILES

O=C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CN[C@@H](C2=CC=CC=C2)C)C3=CC=C(C(N4CCN(C)CC4)=O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ciana CL, et al. Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold. Bioorg Med Chem Lett. 2013 Feb 1;23(3):658-62. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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