Atacicept
Based on 1 publication(s) in Google Scholar
Atacicept (TACI-Ig) is a is a recombinant fusion protein containing the extracellular, ligand-binding portion of the TACI receptor and the Fc portion of human IgG. Atacicept inhibits B cell stimulation by binding to B lymphocyte stimulator and a proliferation-inducing ligand. Atacicept can be used in research of B-cell autoimmune disease.
For research use only. We do not sell to patients.
- Purity: 99.84%
- CAS No.: 845264-92-8
- Molecular Weight:70.45 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Atacicept
More
Biological Activity
[TNFRSF13B]2-IGHG1 Fc
Human
Atacicept (TACI-Ig) inhibits the progression of disease and autoantibody titers in a mouse model of collagen-induced arthritis (CIA)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male DBA/1 mice with CIA models[1]
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Dosage:100 μg
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Administration:intraperitoneal injection; three times of week for 21 days
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Result:Increased serum titers of anti-collagen Abs and few overt signs of disease.
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Animal Model:BALB/c mice[1]
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Dosage:100 μg
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Administration:intraperitoneal injection; three times of week for 14 days
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Result:Reduced mature B cell populations but had little effect on other cell lineages.
Blocked the development of B cells at the transition from T1 to T2 and the development of MZ B cells in the spleen.
Decerased the serum levels of IgM about 2.3-fold.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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[TNFRSF13B (tumor necrosis factor receptor (TNFR)superfamily member 13B, TACI, transmembrane activator and CAML Interactor)]2-IGHG1 Fc (Fragment constant)
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 845264-92-8
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Appearance Liquid
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Molecular Weight 70.45 kDa
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Color Colorless to light yellow
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SMILES
[Atacicept]
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Synonyms
TACI-Ig; TACI-Fc 5
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Gross JA, et, al. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Immunity. 2001 Aug;15(2):289-302. [Content Brief]
[2]. Gross JA, et, al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature. 2000 Apr 27;404(6781):995-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Atacicept Related Classifications
HY-P99446 Related Classifications
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