AGO2 - argonaute RISC catalytic component 2 Gene

Also Known as PPD; Q10; CASC7; EIF2C2; LESKRES; LINC00980

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27161

About AGO2

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:140,520,156-140,642,313 (from NCBI)

This gene has 10 transcripts (splice variants), 211 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in skin (RPKM 3.3), ovary (RPKM 3.3) and 25 other tissues.

Summary

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

AGO2 Products (2)

mRNA	Protein	Name
NM_001164623.3	NP_001158095.1	protein argonaute-2 isoform 2
NM_012154.5	NP_036286.2	protein argonaute-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA 7-methylguanosine cap binding	IDA IDA: Inferred from direct assay	17524464	GOA
enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	18178619	GOA
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	25336585	GOA
enables core promoter sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	25336585	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	19966796	GOA
enables endoribonuclease activity, cleaving miRNA-paired mRNA	IDA IDA: Inferred from direct assay	15260970	GOA
enables endoribonuclease activity, cleaving miRNA-paired mRNA	IMP IMP: Inferred from mutant phenotype	22795694	GOA
enables endoribonuclease activity, cleaving siRNA-paired mRNA	IDA IDA: Inferred from direct assay	15260970	GOA
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	17382880	GOA
enables mRNA cap binding	IDA IDA: Inferred from direct assay	17524464	GOA
enables mRNA cap binding	IPI IPI: Inferred from physical interaction	23409027	GOA
enables miRNA binding	IDA IDA: Inferred from direct assay	15260970	GOA
enables miRNA binding	IPI IPI: Inferred from physical interaction	31012336	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14749716	GOA
contributes to siRNA binding	IDA IDA: Inferred from direct assay	15973356	GOA
enables siRNA binding	IDA IDA: Inferred from direct assay	17495927	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	19966796	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in P-body assembly	IDA IDA: Inferred from direct assay	31400113	GOA
involved in RISC complex assembly	IDA IDA: Inferred from direct assay	19701182	GOA
involved in RNA secondary structure unwinding	IDA IDA: Inferred from direct assay	19966796	GOA
involved in RNA secondary structure unwinding	IMP IMP: Inferred from mutant phenotype	22795694	GOA
involved in miRNA processing	IDA IDA: Inferred from direct assay	19966796	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	17671087	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IMP IMP: Inferred from mutant phenotype	18771919	GOA
involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	15260970	GOA
involved in miRNA-mediated gene silencing by mRNA destabilization	IMP IMP: Inferred from mutant phenotype	18771919	GOA
involved in negative regulation of translational initiation	IDA IDA: Inferred from direct assay	17524464	GOA
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	27208409	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25336585	GOA
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	17382880	GOA
involved in positive regulation of trophoblast cell migration	IMP IMP: Inferred from mutant phenotype	27208409	GOA
involved in pre-miRNA processing	IDA IDA: Inferred from direct assay	16424907	GOA
involved in regulation of synapse maturation	IDA IDA: Inferred from direct assay	29735530	GOA
involved in regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	29735530	GOA
involved in siRNA processing	IDA IDA: Inferred from direct assay	23661684	GOA
involved in siRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	15260970	GOA
involved in siRNA-mediated gene silencing by mRNA destabilization	IMP IMP: Inferred from mutant phenotype	22795694	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	20616046	GOA
part of RISC complex	IDA IDA: Inferred from direct assay	15260970	GOA
part of RISC complex	IGI IGI: Inferred from genetic interaction	31012336	GOA
part of RISC complex	IPI IPI: Inferred from physical interaction	19826008	GOA
part of RISC-loading complex	IDA IDA: Inferred from direct assay	15973356	GOA
part of RISC-loading complex	IPI IPI: Inferred from physical interaction	23661684	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15260970	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	28159509	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	29735530	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	29735530	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23985560	GOA
is active in postsynapse	IDA IDA: Inferred from direct assay	29735530	GOA
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	29735530	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGO2 Protein Structure

ArgoL1

PAZ

Piwi

0
200
400
600
800
859 a.a.

Protein Preferred Names	Protein Names
protein argonaute-2	PAZ Piwi domain protein

AGO2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AGO2	Q9UKV8	MTDH	Homo sapiens	Q86UE4	Anti Tag CoIP	24981741
Intra	AGO2	Q9UKV8	FKBP4	Homo sapiens	Q02790	Anti Bait CoIP	23741051
Intra	AGO2	Q9UKV8	FKBP4	Homo sapiens	Q02790	Anti Tag CoIP	23741051
Intra	AGO2	Q9UKV8	PTGES3	Homo sapiens	Q15185	Anti Tag CoIP	23741051
Intra	AGO2	Q9UKV8	PTGES3	Homo sapiens	Q15185	Anti Bait CoIP	23741051
Intra	AGO2	Q9UKV8	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	AGO2	Q9UKV8	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	AGO2	Q9UKV8	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	AGO2	Q9UKV8	DICER1	Homo sapiens	Q9UPY3-1	Anti Tag CoIP	19955415
Intra	AGO2	Q9UKV8	DICER1	Homo sapiens	Q9UPY3-1	GMS	19820710
Intra	AGO2	Q9UKV8	DICER1	Homo sapiens	Q9UPY3-1	Anti Tag CoIP	23636329
Intra	AGO2	Q9UKV8	DICER1	Homo sapiens	Q9UPY3-1	SLCA	18178619
Intra	AGO2	Q9UKV8	DICER1	Homo sapiens	Q9UPY3-1	GMS	18178619
Intra	AGO2	Q9UKV8	DICER1	Homo sapiens	Q9UPY3-1	Crosslink	19820710
Intra	AGO2	Q9UKV8	DICER1	Homo sapiens	Q9UPY3-1	EM	19820710
Intra	AGO2	Q9UKV8	CNOT7	Homo sapiens	Q9UIV1	Anti Tag CoIP	19716330
Intra	AGO2	Q9UKV8	PLEKHA7	Homo sapiens	Q6IQ23	Confocal	28877994
Intra	AGO2	Q9UKV8	PLEKHA7	Homo sapiens	Q6IQ23	PLA	28877994
Intra	AGO2	Q9UKV8	PLEKHA7	Homo sapiens	Q6IQ23	Anti Bait CoIP	28877994
Intra	AGO2	Q9UKV8	TNRC6A	Homo sapiens	Q8NDV7	Pull Down	19324964
Intra	AGO2	Q9UKV8	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	35271311
Intra	AGO2	Q9UKV8	TNRC6A	Homo sapiens	Q8NDV7	Confocal	28683311
Intra	AGO2	Q9UKV8	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	19716330
Intra	AGO2	Q9UKV8	TNRC6A	Homo sapiens	Q8NDV7	IF	19324964
Intra	AGO2	Q9UKV8	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	23090477
Intra	AGO2	Q9UKV8	TNRC6A	Homo sapiens	Q8NDV7	Anti Bait CoIP	28683311
Intra	AGO2	Q9UKV8	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	28683311
Intra	AGO2	Q9UKV8	TNRC6A	Homo sapiens	Q8NDV7	Anti Bait CoIP	28877994
Intra	AGO2	Q9UKV8	ZMAT3	Homo sapiens	Q9HA38	Anti Tag CoIP	23085987
Intra	AGO2	Q9UKV8	LIMD1	Homo sapiens	Q9UGP4	Anti Bait CoIP	28683311
Intra	AGO2	Q9UKV8	LIMD1	Homo sapiens	Q9UGP4	Anti Tag CoIP	28683311
Intra	AGO2	Q9UKV8	LIMD1	Homo sapiens	Q9UGP4	Pull Down	28683311
Intra	AGO2	Q9UKV8	LIMD1	Homo sapiens	Q9UGP4	PLA	28683311
Intra	AGO2	Q9UKV8	LIMD1	Homo sapiens	Q9UGP4	Confocal	28683311
Intra	AGO2	Q9UKV8	RACK1	Homo sapiens	P63244	Anti Bait CoIP	21525958
Intra	AGO2	Q9UKV8	EGFR	Homo sapiens	P00533	BiFC	23636329
Intra	AGO2	Q9UKV8	EGFR	Homo sapiens	P00533	Pull Down	23636329
Intra	AGO2	Q9UKV8	EGFR	Homo sapiens	P00533	Anti Tag CoIP	23636329
Intra	AGO2	Q9UKV8	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	AGO2	Q9UKV8	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	AGO2	Q9UKV8	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	AGO2	Q9UKV8	DDX6	Homo sapiens	P26196	Confocal	28683311
Intra	AGO2	Q9UKV8	DDX6	Homo sapiens	P26196	Anti Tag CoIP	16756390
Intra	AGO2	Q9UKV8	DDX6	Homo sapiens	P26196	Anti Tag CoIP	28683311
Intra	AGO2	Q9UKV8	DDX6	Homo sapiens	P26196	PLA	28683311
Intra	AGO2	Q9UKV8	DDX6	Homo sapiens	P26196	FRET	16756390
Intra	AGO2	Q9UKV8	DDX6	Homo sapiens	P26196	Anti Bait CoIP	28683311
Intra	AGO2	Q9UKV8	IPO8	Homo sapiens	O15397	Anti Tag CoIP	17932509
Intra	AGO2	Q9UKV8	IPO8	Homo sapiens	O15397	Anti Tag CoIP	19167051
Intra	AGO2	Q9UKV8	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	19716330
Intra	AGO2	Q9UKV8	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	23622242
Intra	AGO2	Q9UKV8	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	26496610
Intra	AGO2	Q9UKV8	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	23741051
Intra	AGO2	Q9UKV8	DICER1	Homo sapiens	Q9UPY3	GMS	23622242
Intra	AGO2	Q9UKV8	DICER1	Homo sapiens	Q9UPY3	Density Sedimentation	14749716
Intra	AGO2	Q9UKV8	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	33961781
Intra	AGO2	Q9UKV8	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	17932509
Intra	AGO2	Q9UKV8	RB1	Homo sapiens	P06400	Anti Bait CoIP	22366686
Intra	AGO2	Q9UKV8	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	AGO2	Q9UKV8	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	AGO2	Q9UKV8	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	AGO2	Q9UKV8	AGO1	Homo sapiens	Q9UL18	Anti Tag CoIP	16756390
Intra	AGO2	Q9UKV8	AGO1	Homo sapiens	Q9UL18	Anti Tag CoIP	35271311
Intra	AGO2	Q9UKV8	AGO1	Homo sapiens	Q9UL18	FRET	16756390
Intra	AGO2	Q9UKV8	LRRK2	Homo sapiens	Q5S007	Anti Bait CoIP	20671708
Intra	AGO2	Q9UKV8	GNL3	Homo sapiens	Q9BVP2	Anti Bait CoIP	24550003
Intra	AGO2	Q9UKV8	GNL3	Homo sapiens	Q9BVP2	Anti Tag CoIP	17932509
Intra	AGO2	Q9UKV8	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	21981923
Intra	AGO2	Q9UKV8	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	35271311
Intra	AGO2	Q9UKV8	TNRC6C	Homo sapiens	Q9HCJ0	Confocal	19383768
Intra	AGO2	Q9UKV8	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	19383768
Intra	AGO2	Q9UKV8	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	19838187
Intra	AGO2	Q9UKV8	TNRC6B	Homo sapiens	Q9UPQ9-2	Anti Tag CoIP	19383768
Intra	AGO2	Q9UKV8	PRKRA	Homo sapiens	O75569	Anti Tag CoIP	16424907
Intra	AGO2	Q9UKV8	EIF4EBP1	Homo sapiens	Q13541	Anti Tag CoIP	20671708
Intra	AGO2	Q9UKV8	TNRC6B	Homo sapiens	Q9UPQ9	Anti Tag CoIP	17932509
Intra	AGO2	Q9UKV8	TNRC6B	Homo sapiens	Q9UPQ9	Confocal	19383768
Intra	AGO2	Q9UKV8	TNRC6B	Homo sapiens	Q9UPQ9	Anti Tag CoIP	19838187
Intra	AGO2	Q9UKV8	TNRC6B	Homo sapiens	Q9UPQ9	Anti Tag CoIP	35271311
Intra	AGO2	Q9UKV8	TNRC6B	Homo sapiens	Q9UPQ9	Pull Down	19716330
Intra	AGO2	Q9UKV8	TNRC6B	Homo sapiens	Q9UPQ9	Peptide Array	24043833
Intra	AGO2	Q9UKV8	TNRC6B	Homo sapiens	Q9UPQ9	FPS	24043833
Intra	AGO2	Q9UKV8	PRNP	Homo sapiens	P04156	Anti Bait CoIP	22484317
Intra	AGO2	Q9UKV8	TARBP2	Homo sapiens	Q15633	Anti Tag CoIP	19716330
Intra	AGO2	Q9UKV8	TARBP2	Homo sapiens	Q15633	Anti Tag CoIP	23622242
Intra	AGO2	Q9UKV8	TARBP2	Homo sapiens	Q15633	GMS	19820710
Intra	AGO2	Q9UKV8	TARBP2	Homo sapiens	Q15633	SLCA	18178619
Intra	AGO2	Q9UKV8	TARBP2	Homo sapiens	Q15633	GMS	18178619
Intra	AGO2	Q9UKV8	TARBP2	Homo sapiens	Q15633	Anti Tag CoIP	17932509
Intra	AGO2	Q9UKV8	TARBP2	Homo sapiens	Q15633	Crosslink	19820710
Intra	AGO2	Q9UKV8	TARBP2	Homo sapiens	Q15633	Anti Tag CoIP	23636329
Intra	AGO2	Q9UKV8	TARBP2	Homo sapiens	Q15633	EM	19820710

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AGO2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72835	AGO2/Argonaute-2 Protein, Human (sf9, His)	Q9UKV8 (M1-A859)	≥ 90%, as determined by reducing SDS-PAGE.

AGO2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80441	Argonaute 2 Antibody (YA612)	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse
HY-P80546	Argonaute 2 Antibody	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P86098	Argonaute 2 Antibody (YA5790)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Lessel-Kreienkamp Syndrome	LESKRES
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Eunuchism
Patau Syndrome	Trisomy 13 Complete Trisomy 13 Syndrome Trisomy 13 Syndrome D1 Trisomy Patau'S Syndrome Complete Trisomy 13 Chromosome 13, Trisomy 13 Complete D Trisomy Syndrome Bartholin-Patau Syndrome Chromosome 13 Duplication D1 Trisomy Syndrome D>1< Trisomy Syndrome Patau Chromosome 13 Trisomy Abnormal Autosomes 13
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Orofaciodigital Syndrome Viii	Edwards Syndrome Trisomy 18 Complete Trisomy 18 Syndrome OFD8 Orofaciodigital Syndrome 8 Trisomy 18 Syndrome Oral-Facial-Digital Syndrome With Hypoplastic Epiglottis E3 Trisomy Oral-Facial-Digital Syndrome Type 8 Orofaciodigital Syndrome Type 8 Ofds Viii Oral-Facial-Digital Syndrome, Type Viii Ofd Syndrome 8 Ofds 8 Oral Facial Digital Syndrome 8 Oral Facial Digital Syndrome Type 8 18 Trisomy Chromosome 18 Trisomy Trisomy 16-18 Trisomy E Trisomy E Syndrome Chromosome 18 Duplication Oral-Facial-Digital Syndrome, Edwards Type Orofaciodigital Syndrome, Edwards Type Chromosome 18, Trisomy Cleft Lip/Palate With Abnormal Thumbs And Microcephaly Trisomy 18 Chromosome Abnormal Autosomes 18
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Cervical Non-Keratinizing Squamous Cell Carcinoma
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119024	BCI-137		99.84%	Unkown
HY-RS00453	AGO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17683	Ago2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24144	Ago2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AGO2	RGD	RGD:621255
Mus musculus	AGO2	MGD	MGI:2446632
Felis catus	AGO2	VGNC	VGNC:81639
Canis familiaris	AGO2	VGNC	VGNC:37707
Bos taurus	AGO2	VGNC	VGNC:50167
Macaca mulatta	AGO2	VGNC	VGNC:81347
Others	AGO2	NCBI