(S)-C33
Based on 1 Customer Validation
(S)-C33 is a potent and selective PDE9 (phosphodiesterase-9) inhibitor, with an IC50 of 11 nM. (S)-C33 can be used for central nervous system diseases and diabetes research.
For research use only. We do not sell to patients.
- Purity : 99.46%
- CAS No.: 2066488-39-7
- Formula: C18H20ClN5O
- Molecular Weight:357.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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PDE9A 11 nM (IC50) |
PDE5A1 366 nM (IC50) |
PDE1B 554 nM (IC50) |
PDE4D2 1.3 μM (IC50) |
PDE10A1 2.3 μM (IC50) |
PDE2A 2.4 μM (IC50) |
In Vitro
(S)-C33 shows the T1/2 values of 105 and 54 minutes in human and mouse microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2066488-39-7
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Appearance Solid
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Molecular Weight 357.84
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Formula C18H20ClN5O
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Color White to off-white
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SMILES
O=C1C2=C(N(C3CCCC3)N=C2)N=C(N[C@H](C4=CC=C(Cl)C=C4)C)N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (279.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7945 mL | 13.9727 mL | 27.9455 mL | 69.8636 mL |
| 5 mM | 0.5589 mL | 2.7945 mL | 5.5891 mL | 13.9727 mL | |
| 10 mM | 0.2795 mL | 1.3973 mL | 2.7945 mL | 6.9864 mL | |
| 15 mM | 0.1863 mL | 0.9315 mL | 1.8630 mL | 4.6576 mL | |
| 20 mM | 0.1397 mL | 0.6986 mL | 1.3973 mL | 3.4932 mL | |
| 25 mM | 0.1118 mL | 0.5589 mL | 1.1178 mL | 2.7945 mL | |
| 30 mM | 0.0932 mL | 0.4658 mL | 0.9315 mL | 2.3288 mL | |
| 40 mM | 0.0699 mL | 0.3493 mL | 0.6986 mL | 1.7466 mL | |
| 50 mM | 0.0559 mL | 0.2795 mL | 0.5589 mL | 1.3973 mL | |
| 60 mM | 0.0466 mL | 0.2329 mL | 0.4658 mL | 1.1644 mL | |
| 80 mM | 0.0349 mL | 0.1747 mL | 0.3493 mL | 0.8733 mL | |
| 100 mM | 0.0279 mL | 0.1397 mL | 0.2795 mL | 0.6986 mL |
(S)-C33 Related Classifications
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