Tropine
Based on 1 Customer Validation
Tropine is a tropane alkaloid. Tropine serves as an important intermediate for the synthesis of anticholinergics and bronchodilators such as Atropine (HY-B1205) and Scopolamine (HY-N0296).
For research use only. We do not sell to patients.
- Purity: 99.99%
- CAS No.: 120-29-6
- Formula: C8H15NO
- Molecular Weight:141.21
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Sprague Dawley rats treated Fentanyl[2]
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Dosage:200 μmol/kg
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Administration:Intravenous injection; single dose
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Result:Exacerbated fentanyl-induced decreases in respiratory frequency, tidal volume, and minute ventilation, prolonged expiratory time, and worsened arterial blood gas parameters (decreased pH, pO₂, sO₂, and increased pCO₂).
Prolonged the duration of fentanyl-induced sedation (righting reflex recovery time) but did not affect fentanyl-induced antinociception (tail-flick latency).
Chemical Information
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CAS No. 120-29-6
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Appearance Solid
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Molecular Weight 141.21
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Formula C8H15NO
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Color White to off-white
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SMILES
CN1[C@@]2([H])C[C@@H](C[C@]1([H])CC2)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (708.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (354.08 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (17.70 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (17.70 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Grynkiewicz G, et al. Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs.Pharmacol Rep. 2008 Jul-Aug;60(4):439-63. [Content Brief]
[2]. Getsy PM, et al. Tropine exacerbates the ventilatory depressant actions of fentanyl in freely-moving rats. Front Pharmacol. 2024 Jun 24;15:1405461. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 7.0817 mL | 35.4083 mL | 70.8165 mL | 177.0413 mL |
| 5 mM | 1.4163 mL | 7.0817 mL | 14.1633 mL | 35.4083 mL | |
| 10 mM | 0.7082 mL | 3.5408 mL | 7.0817 mL | 17.7041 mL | |
| 15 mM | 0.4721 mL | 2.3606 mL | 4.7211 mL | 11.8028 mL | |
| 20 mM | 0.3541 mL | 1.7704 mL | 3.5408 mL | 8.8521 mL | |
| 25 mM | 0.2833 mL | 1.4163 mL | 2.8327 mL | 7.0817 mL | |
| 30 mM | 0.2361 mL | 1.1803 mL | 2.3606 mL | 5.9014 mL | |
| 40 mM | 0.1770 mL | 0.8852 mL | 1.7704 mL | 4.4260 mL | |
| 50 mM | 0.1416 mL | 0.7082 mL | 1.4163 mL | 3.5408 mL | |
| 60 mM | 0.1180 mL | 0.5901 mL | 1.1803 mL | 2.9507 mL | |
| 80 mM | 0.0885 mL | 0.4426 mL | 0.8852 mL | 2.2130 mL | |
| 100 mM | 0.0708 mL | 0.3541 mL | 0.7082 mL | 1.7704 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tropine Related Classifications
HY-N7061 Related Classifications
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