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United States

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Cat. No.: HY-P10386

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155H1

155H1 (Compound 11) is a stapled peptide, that covalently binds hMcl1 (172-323) with IC₅₀ of 18 nM.

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화학식: C₇₉H₁₂₀FN₁₉O₂₃S
분자량:1754.98

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

155H1 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

155H1 (Compound 11) is a stapled peptide, that covalently binds hMcl1 (172-323) with IC₅₀ of 18 nM^[1].

All Bcl-2 Family Isoforms :

Chemical Information

분자량 1754.98
화학식 C₇₉H₁₂₀FN₁₉O₂₃S
Sequence

Ac-{Dap(2MeO,5FSB)}-Ile-Ala-Glu-Gln-Leu-Arg-{(S)-2-(4-pentenyl)Ala}-Ile-Gly-Asp-{(S)-2-(4-pentenyl)Ala}-Phe-CONH2 (2MeO,5FSB=2-methoxy, 5-sulfonyl fluoride)
Sequence Shortening

Ac-{Dap(2MeO,5FSB)}-IAEQLR-{(S)-2-(4-pentenyl)Ala}-IGD-{(S)-2-(4-pentenyl)Ala}-F-CONH2 (2MeO,5FSB=2-methoxy, 5-sulfonyl fluoride)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Alboreggia G, et al., Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl-1. J Med Chem. 2024 May 23;67(10):8172-8185. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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