447C88
447C88 is an acyl-coenzyme A cholesterol acyltransferase (ACAT) inhibitor with an IC50 of 23 nM. 447C88 can reduce plasma cholesterol levels and can be used in the research of endocrine and metabolic diseases such as hyperlipidemia.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 130400-16-7
- 화학식: C27H38F2N2O
- 분자량:444.60
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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ACAT 23 nM (IC50) |
Chemical Information
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CAS No. 130400-16-7
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분자량 444.60
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화학식 C27H38F2N2O
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SMILES
O=C(NCCCCCCC)NC1=C(F)C=C(F)C=C1CCC2=CC=C(CC(C)(C)C)C=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Fraser IJ, et al. Determination of the acylcoenzyme A cholesterol acyltransferase inhibitor 447C88 in plasma using gas chromatography-mass spectrometry and liquid chromatography atmospheric pressure chemical ionisation tandem mass spectrometry. J Chromatogr B Biomed Appl. 1995 Jan 20;663(2):275-87. [Content Brief]
[2]. Peck RW, et al. The tolerability, pharmacokinetics and lack of effect on plasma cholesterol of 447C88, an AcylCoA: Cholesterol Acyl Transferase (ACAT) inhibitor with low bioavailability, in healthy volunteers. Eur J Clin Pharmacol. 1995;49(3):243-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
447C88 Related Classifications
HY-19112 Related Classifications
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